1,2-Diphenyl-2-(pyrrolidin-1-yl)ethanol

Base Information

• Chemical Name: 1,2-Diphenyl-2-(pyrrolidin-1-yl)ethanol
• CAS No.: 17244-79-0
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.371
• NSC Number: 133511,133496
• DSSTox Substance ID: DTXSID10299882
• Nikkaji Number: J3.628.109J
• Mol file: 17244-79-0.mol

Synonyms:17244-79-0;1,2-diphenyl-2-(pyrrolidin-1-yl)ethanol;NSC133511;SCHEMBL23496077;DTXSID10299882;NSC133496;AKOS011033243;NSC-133496;NSC-133511

Chemical Property of 1,2-Diphenyl-2-(pyrrolidin-1-yl)ethanol

Chemical Property:

• Vapor Pressure: 1.42E-06mmHg at 25°C
• Boiling Point: 383.8°Cat760mmHg
• Flash Point: 175.8°C
• Density: 1.141g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 267.162314293
• Heavy Atom Count: 20
• Complexity: 275

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)C(C2=CC=CC=C2)C(C3=CC=CC=C3)O

Technology Process of 1,2-Diphenyl-2-(pyrrolidin-1-yl)ethanol

There total 2 articles about 1,2-Diphenyl-2-(pyrrolidin-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyrrolidine (123-75-1) + cis-1,2-diphenyloxirane (1689-71-0) → (R*,R*)-1,2-diphenyl-2-pyrrolidin-1-yl-ethanol (17244-79-0,17244-80-3,19640-38-1,19640-39-2,123074-81-7)

Guidance literature:

In toluene; for 24h; Heating;

DOI:10.1016/S0957-4166(03)00367-7

Reference yield: 62.0%

pyrrolidine (123-75-1) + trans-Stilbene oxide (1439-07-2) → erythro-2-pyrrolidinyl-1,2-diphenylethanol (17244-79-0,17244-80-3,19640-38-1,19640-39-2,123074-81-7)

Guidance literature:

Heating;

Reference yield: 99.0%

(R*,R*)-1,2-diphenyl-2-pyrrolidin-1-yl-ethanol (17244-79-0,17244-80-3,19640-38-1,19640-39-2,123074-81-7) → (R*,R*)-1-chloro-1,2-diphenyl-2-pyrrolidin-1-yl-ethane

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0957-4166(03)00367-7

upstream raw materials:

pyrrolidine

trans-Stilbene oxide

cis-1,2-diphenyloxirane

Downstream raw materials:

morpholine

benzaldehyde