5-Chloro-8-iodo-1,6-naphthyridine

Base Information

• Chemical Name: 5-Chloro-8-iodo-1,6-naphthyridine
• CAS No.: 107484-69-5
• Molecular Formula: C8H4ClIN2
• Molecular Weight: 290.48823
• European Community (EC) Number: 958-182-0
• DSSTox Substance ID: DTXSID40602300
• Wikidata: Q82499293
• Mol file: 107484-69-5.mol

Synonyms:5-chloro-8-iodo-1,6-naphthyridine;107484-69-5;1,6-Naphthyridine, 5-chloro-8-iodo-;SCHEMBL9189341;DTXSID40602300;MFCD16250553;AKOS022171595;DS-5651;SB74504;5-Chloro-8-iodo-1,6-naphthyridine, 95%;CS-0097704;C71288;A907792

Chemical Property of 5-Chloro-8-iodo-1,6-naphthyridine

Chemical Property:

• Boiling Point: 383.2±37.0 °C(Predicted)
• PKA: 0.02±0.30(Predicted)
• PSA: 25.78000
• Density: 2.017±0.06 g/cm3(Predicted)
• LogP: 2.88780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 289.91077
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-8-iodo-1,6-naphthyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=CN=C2Cl)I)N=C1

Technology Process of 5-Chloro-8-iodo-1,6-naphthyridine

There total 2 articles about 5-Chloro-8-iodo-1,6-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

8-iodo-1,6-naphthyridin-5(6H)-one (107484-68-4) → 5-chloro-8-iodo-1,6-naphthyridine (107484-69-5)

Guidance literature:

With trichlorophosphate; for 1.5h; Heating;

Reference yield:

1,6-naphthyridine-5(6H)-one (23616-31-1) → 5-chloro-8-iodo-1,6-naphthyridine (107484-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / I₂, 0.4 N NaOH / 3 h / 80 °C

2: 64 percent / POCl₃ / 1.5 h / Heating

With sodium hydroxide; iodine; trichlorophosphate;

upstream raw materials:

8-iodo-1,6-naphthyridin-5(6H)-one

1,6-naphthyridine-5(6H)-one