23616-31-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1,6-Naphthyridin-5(6H)-one is utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its anti-inflammatory and anti-microbial properties make it a valuable component in the development of new drugs, contributing to the advancement of treatments for a range of conditions and diseases.
Used in Corrosion Inhibition:
1,6-Naphthyridin-5(6H)-one is being researched for its potential as a corrosion inhibitor. This application is significant in industries where materials are exposed to corrosive environments, such as in the manufacturing of metal components and in the maintenance of infrastructure. Its effectiveness in preventing corrosion could lead to increased durability and reduced maintenance costs.
Used in Fluorescent Dyes:
Additionally, 1,6-Naphthyridin-5(6H)-one is being explored as a component in fluorescent dyes. This application is relevant in fields that require sensitive detection and imaging techniques, such as in medical diagnostics, forensic science, and research laboratories. 1,6-Naphthyridin-5(6H)-one's potential to enhance the performance of fluorescent dyes could lead to improved detection capabilities and more accurate analytical results.

InChI:InChI=1/C8H6N2O/c11-8-6-2-1-4-9-7(6)3-5-10-8/h1-5H,(H,10,11)

Upstream product

• 106837-37-0 2-(2-hydroxy-ethyl)-nicotinic acid amide 
• 97308-56-0 2-(2,2-dimethoxy-ethyl)-nicotinamide 
• 58539-65-4 2-methylnicotinamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 79-37-8 oxalyl dichloride 
• 65719-09-7 methyl 2-methylnicotinate 
• 97308-49-1 2-trimethylsilylethynyl-3-pyridinecarbonitrile 
• 97308-52-6 2-(β,β-dimethoxyethyl)-3-pyridinecarbonitrile 
• 3222-56-8 2-methylnicotinic acid 
• 5860-72-0 7,8-dihydro-5H-pyrano[4,3-b]pyridin-5-one 
• 169229-06-5 2-methylnicotinoyl chloride 

Downstream Products

• 23616-32-2 5-chloro-[1,6]naphthyridine 
• 444898-55-9 C₃₄H₂₆N₂O₈ 
• 155057-98-0 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H)-one 
• 155057-97-9 8-bromo-5,6-dihydro-1,6-naphthyridin-5-one 
• 909649-12-3 4-bromo-1-chloro-1,6-naphthyridine 
• 107484-69-5 5-chloro-8-iodo-1,6-naphthyridine 
• 253-72-5 1,6-naphthyridine 
• 1201844-65-6 N-(2-chloro-5-(5-oxo-1,6-naphthyridin-6(5H)-yl)-3-pyridinyl)-4-fluorobenzenesulfonamide 
• 55570-60-0 1,6-naphthyridin-5-amine 
• 1351516-79-4 6-Amino-1,6-naphthyridin-5(6H)-iminium-2,4,6-trimethylbenzenesulfonate 
• 23616-35-5 2,5-dichloro-1,6-naphthyridine 
• 1516896-09-5 3-methyl-2-((1S,2S)-2-(quinolin-2-yl)cyclopropyl)-3H-imidazo[4,5-f]quinoline 
• 1516896-06-2 C₂₁H₁₉N₇ 
• 1516895-53-6 trans-2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)-3-methylimidazo[2,1-f][1,6]naphthyridine 

Relevant academic research and scientific papers

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

ANTI-FIBROTIC PYRIDINONES

This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments comprising said compounds and methods to treat, prevent or diagnose diseases, disorders or conditions associated with fibrosis.

ANTI-FIBROTIC PYRIDINONES

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Ready access to 7,8-dihydro- and 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H) -ones from simple pyridine precursors

Short pathways are described for the synthesis of a representative example of each of the 7,8-dihydro- and 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H)-one ring systems from simple pyridine precursors. An attempted synthesis of the related 4,6-dihydro-1,6-naphthyridin-5(1H)-one ring system from a common intermediate was unsuccessful.

Dihydro- and tetrahydronaphthyridines

This invention concerns novel dihydro- and tetrahydronaphthyridines useful for enhancing the lethal effects on tumor cells to treatment causing DNA-damaging activity as with ionizing radiation or with a chemotherapeutic agent.

Condensed Heteroaromatic Ring Systems. III. Synthesis of Naphthyridine Derivatives by Cyclization of Ethynylpyridinecarboxamides

Four kinds of naphthyridinones, i.e. 1,6-naphthyridin-5-one, 1,7-naphthyridin-8-one, 2,6-naphthyridin-2-one, and 2,7-naphthyridin-1-one derivatives, were commonly synthesized by the intramolecular cyclization of pyridinecarboxamides having an ethynyl group or β,β-dimethoxyethyl group adjacent to the carbamoyl group.The syntheses of the starting pyridine derivatives were easily accomplished by cross-coupling of the corresponding halopyridines with acetylenes.Keywords-intramolecular cyclization; palladium catalyst; trimethylsilylacetylene; naphthyridinone; pyridineacetaldehyde; 1(2H)-isoquinolone

NOVEL NAPHTHYRIDINES

Novel naphthyridines having a 3-amino-2-OR-propoxy substituent are disclosed. The compounds have β-adrenergic blocking and immediate onset antihypertensive activities.