2-PentanaMine, hydrochloride (1:1), (2S)-

Base Information

• Chemical Name: 2-PentanaMine, hydrochloride (1:1), (2S)-
• CAS No.: 216237-52-4
• Molecular Formula: C5H14ClN
• Molecular Weight: 123.62436
• Mol file: 216237-52-4.mol

Synonyms:2-PentanaMine, hydrochloride (1:1), (2S)-;(2S)-pentan-2-amine hydrochloride;(S)-Pentan-2-amine hydrochloride;(2S)-Pentanamine hydrochloride

Chemical Property of 2-PentanaMine, hydrochloride (1:1), (2S)-

Chemical Property:

• PSA: 26.02000
• LogP: 2.63600
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Ethanol (Sparingly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

(2S)-2-PentanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-PentanaMine, hydrochloride (1:1), (2S)-

There total 2 articles about 2-PentanaMine, hydrochloride (1:1), (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2-pentanol (6032-29-7,13403-73-1) → 2-Pentanone (107-87-9) + (R)-(+)-(1-methylbutyl)amine hydrochloride (101689-05-8,216237-52-4)

Guidance literature:

(+/-)-2-pentanol; With alcohol dehydrogenase from Streptomyces coelicolor; leucine dehydrogenase from Exiguobactertium sibiricum K₇₇S/N₂₇₀L double mutant; NADH; at 30 ℃; for 24h; pH=8.5; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; pH-value; stereoselective reaction;

DOI:10.1002/cctc.201500785

Reference yield:

pentane (109-66-0,8031-35-4,9078-70-0) → 1-methyl-butylamine hydrochloride (76716-21-7,101689-05-8,216237-52-4) + pentan-3-amine hydrochloride (5398-26-5) + n-pentylamine hydrochloride (142-65-4)

Guidance literature:

pentane; With cerium(III) chloride; 1,1,1-trichloroethanol; di-tert-butyl-diazodicarboxylate; tetrabutyl-ammonium chloride; In acetonitrile; at 20 ℃; for 12h; Irradiation; Inert atmosphere; Sealed tube;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Reagent/catalyst; Further stages;

DOI:10.1021/jacs.0c00212

Reference yield: 71.0%

(S)-1-methylbutylamine hydrochloride (216237-52-4) + isopropyl 6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-chloro-5-fluoronicotinate → (S)-isopropyl 6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-(pentan-2-ylamino)nicotinate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; cesium fluoride; In dimethyl sulfoxide; at 100 ℃; for 6h;

upstream raw materials:

pentane

(+/-)-2-pentanol

Downstream raw materials:

C₁₅H₂₀F₃NO₂

[4-(2,4-dichloro-phenyl)-3-nitro-pyridin-2-yl]-(1-methyl-butyl)-amine

(R)-3,3,3-Trifluoro-2-methoxy-N-((R)-1-methyl-butyl)-2-phenyl-propionamide

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