Mecillinam

Base Information

Chemical Name:Mecillinam
CAS No.:32887-01-7
Deprecated CAS:51556-89-9,70178-27-7,73937-07-2,79580-20-4
Molecular Formula:C₁₅H₂₃N₃O₃S
Molecular Weight:325.432
Hs Code.:
European Community (EC) Number:251-277-1
UNII:V10579P3QZ
DSSTox Substance ID:DTXSID3022584
Nikkaji Number:J19.342I
Wikipedia:Mecillinam
Wikidata:Q13019044
NCI Thesaurus Code:C65229
Metabolomics Workbench ID:57656
ChEMBL ID:CHEMBL530,CHEMBL258646
Mol file:32887-01-7.mol

Synonyms:Amdinocillin;FL 1060;FL-1060;FL1060;Mecillinam;Penicillin Hx

Suppliers and Price of Mecillinam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Amdinocillin
1g
$ 340.00

TRC
Amdinocillin
1g
$ 480.00

Sigma-Aldrich
Mecillinam VETRANAL
100mg
$ 160.00

Medical Isotopes, Inc.
Amdinocillin
0.5 g
$ 2000.00

Medical Isotopes, Inc.
Amdinocillin
100 mg
$ 875.00

Crysdot
Mecillinam 95+%
100g
$ 1126.00

Crysdot
Mecillinam 95+%
25g
$ 414.00

Crysdot
Mecillinam 95+%
10g
$ 198.00

Crysdot
Mecillinam 95+%
5g
$ 104.00

ChemScene
Mecillinam
10mg
$ 70.00

Total 80 raw suppliers

Chemical Property of Mecillinam

Chemical Property:

Appearance/Colour:White solid
Vapor Pressure:0mmHg at 25°C
Melting Point:156 °C
Refractive Index:1.686
Boiling Point:550.553 °C at 760 mmHg
PKA:pKa 3.40 (Uncertain)
Flash Point:286.764 °C
PSA：98.51000
Density:1.447 g/cm³
LogP:1.28200
Storage Temp.:Store at?0-5°C
Solubility.:Methanol (Slightly), Water (Slightly)
Water Solubility.:Soluble in water at approximately 1mg/ml
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:325.14601278
Heavy Atom Count:22
Complexity:500

Purity/Quality:

97% ^*data from raw suppliers

Amdinocillin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1(C(N2C(S1)C(C2=O)N=CN3CCCCCC3)C(=O)O)C
Isomeric SMILES:CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)N=CN3CCCCCC3)C(=O)O)C
Recent ClinicalTrials:Ibuprofen Versus Mecillinam for Uncomplicated Cystitis
Recent EU Clinical Trials:Short course antibiotic treatment of Gram-negative bacteremia: A multicenter, randomized, non-blinded, non-inferiority interventional study
Uses Effective against Gram-negative bacteria Active antibacterial against gram-negative bacteria Mecillinam (amidinocillin) is a penicillin nucleus (6 APA) derivative, active in vitro against most aerobic and anaerobic Gram-negative bacilli, including E. coli and B. fraglis, but not active against Staphylococcus aureus, Enterococcus, or Pseudomonas. Mecillinam is synergistic with other beta-lactam drugs and therefore can be used in combination to treat severe Gram-negative infections. Although its in vitro efficacy is convincing, there are not enough clinical trials to support its use for intra-abdominal infections.
Therapeutic Function Antibacterial
Clinical Use Urinary tract infection (pivmecillinam) Other infections with susceptible Gram-negative bacilli (usually in combination with other agents)

Technology Process of Mecillinam

There total 5 articles about Mecillinam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: