5-(3,3-Difluoro-cyclobutyl)-2H-pyrazol-3-ylaMine

Base Information

• Chemical Name: 5-(3,3-Difluoro-cyclobutyl)-2H-pyrazol-3-ylaMine
• CAS No.: 1425931-95-8
• Molecular Formula: C7H9F2N3
• Molecular Weight: 173.1632664
• Hs Code.: 2933199090
• Mol file: 1425931-95-8.mol

Synonyms:5-(3,3-Difluoro-cyclobutyl)-2H-pyrazol-3-ylaMine;5-(3,3-difluorocyclobutyl)-1H-pyrazol-3-amine

Chemical Property of 5-(3,3-Difluoro-cyclobutyl)-2H-pyrazol-3-ylaMine

Chemical Property:

• PSA: 54.70000
• LogP: 2.08580

Purity/Quality:

97% ^*data from raw suppliers

5-(3,3-Difluorocyclobutyl)-1H-pyrazol-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3,3-Difluoro-cyclobutyl)-2H-pyrazol-3-ylaMine

There total 5 articles about 5-(3,3-Difluoro-cyclobutyl)-2H-pyrazol-3-ylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3,3-difluorocyclobutyl)-3-oxopropanenitrile (1234616-26-2) → 5-(3,3-difluorocyclobutyl)-1H-pyrazol-3-amine (1425931-95-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 75 ℃;

Reference yield:

4-methoxybenzyl 3-oxocyclobutanecarboxylate (1425931-93-6) → 5-(3,3-difluorocyclobutyl)-1H-pyrazol-3-amine (1425931-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: DAST / dichloromethane / 20 °C

2.1: sodium hydride / 1,4-dioxane / 0.33 h

2.2: 4 h / Reflux

3.1: hydrazine hydrate / ethanol / 75 °C

With sodium hydride; hydrazine hydrate; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

3-oxocyclobutanecarboxylic acid (23761-23-1) → 5-(3,3-difluorocyclobutyl)-1H-pyrazol-3-amine (1425931-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate; tetrabutylammomium bromide / dichloromethane; water / 20 °C

2.1: DAST / dichloromethane / 20 °C

3.1: sodium hydride / 1,4-dioxane / 0.33 h

3.2: 4 h / Reflux

4.1: hydrazine hydrate / ethanol / 75 °C

With tetrabutylammomium bromide; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; dichloromethane; water;

upstream raw materials:

4-methoxybenzyl 3-oxocyclobutanecarboxylate

3-oxocyclobutanecarboxylic acid

4-methoxybenzyl 3,3-difluorocyclobutanecarboxylate

3-(3,3-difluorocyclobutyl)-3-oxopropanenitrile

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