23761-23-1Relevant articles and documents
Preparation method 3 - oxocyclobutane-based carboxylic acid
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Paragraph 0033-0035, (2021/10/27)
The invention discloses a preparation method of 3 -oxocyclobutane-based carboxylic acid, and belongs to the technical field of synthesis of medical intermediates. The ketone is protected from 1, 3 -dihydroxyacetone by condensation with trimethyl orthoformate to give 2, 2 -dimethoxy -1, 3 -propanediol, followed by reaction with malonate to give 3, 3 -dimethylcyclobutyl -1, 1 -dicarboxylic acid diester, followed by hydrolysis under acidic conditions. Decarboxylation and deprotection to yield 3 -oxocyclobutane-based carboxylic acids. The method has the advantages of high yield, common and easily available raw materials, simple flow and industrial amplification prospect.
Preparation method of 3-oxocyclobutylcarboxylic acid
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Paragraph 0028-0084, (2019/01/24)
The invention belongs to the technical field of organic synthesis, and specifically relates to a preparation method of 3-oxocyclobutylcarboxylic acid. According to the preparation method, 3,3-dimethoxylcyclobutyl-1,1-diisopropyl dicarboxylate, methanol, and sodium hydroxide are taken as the raw materials, and raw materials react with hydrochloric acid to prepare 3-oxocyclobutylcarboxylic acid. Thereactions are quick, the method is simple, the technology is safe, the raw materials are easily available and cheap, the yield of the two-step reactions can reach 80% or more, and the production purity and yield are effectively increased.
ANTIBACTERIAL AGENTS
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Page/Page column 105, (2014/10/18)
Antibacterial compounds of formula (I) are provided, as well as stereoisomers and pharmaceutically acceptable salts and esters thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.