1-Boc-2,2-diMethylpyrrolidine

Base Information

• Chemical Name: 1-Boc-2,2-diMethylpyrrolidine
• CAS No.: 869527-80-0
• Molecular Formula: C₁₁H₂₁NO₂
• Molecular Weight: 199.293
• Hs Code.: 2933990090
• Mol file: 869527-80-0.mol

Synonyms:1-Boc-2,2-diMethylpyrrolidine;tert-Butyl 2,2-diMethylpyrrolidine-1-carboxylate;2,2-Dimethylpyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of 1-Boc-2,2-diMethylpyrrolidine

Chemical Property:

• Boiling Point: 241.9±9.0 °C(Predicted)
• PKA: -1.15±0.40(Predicted)
• PSA: 29.54000
• Density: 0.970±0.06 g/cm3(Predicted)
• LogP: 2.73380
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2,2-dimethylpyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-2,2-diMethylpyrrolidine

There total 3 articles about 1-Boc-2,2-diMethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-azido-4-methylpentane + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 2,2-dimethylpyrrolidine-1-carboxylate (869527-80-0)

Guidance literature:

With [Fe^III(5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato)(1,3-dimethylimidazol-2-ylidene)₂]I; In toluene; at 115 ℃; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1002/anie.201806059

Reference yield: 48.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + di-tert-butyl dicarbonate (24424-99-5) + thiophenol (108-98-5) → tert-butyl 2,2-dimethylpyrrolidine-1-carboxylate (869527-80-0)

Guidance literature:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; thiophenol; With potassium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 12h; Inert atmosphere;

di-tert-butyl dicarbonate; In methanol; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c9ob00018f

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-azido-2-methylpentane (91633-21-5) → tert-butyl 2,2-dimethylpyrrolidine-1-carboxylate (869527-80-0)

Guidance literature:

With (1,9-adamantyl-5-(2,6-Cl₂C₆H₃)-dipyrrin)FeCl(OEt₂); In benzene; at 65 ℃; for 12h;

upstream raw materials:

di-tert-butyl dicarbonate

2-azido-2-methylpentane

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

thiophenol