10-Benzyl-8-oxa-3,10-diaza-bicyclo[4.3.1]decane

Base Information

• Chemical Name: 10-Benzyl-8-oxa-3,10-diaza-bicyclo[4.3.1]decane
• CAS No.: 1085458-63-4
• Molecular Formula: C14H20N2O
• Molecular Weight: 232.326
• Mol file: 1085458-63-4.mol

Synonyms:10-Benzyl-8-oxa-3,10-diaza-bicyclo[4.3.1]decane

Chemical Property of 10-Benzyl-8-oxa-3,10-diaza-bicyclo[4.3.1]decane

Chemical Property:

• PSA: 24.50000
• LogP: 1.51600

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-Benzyl-8-oxa-3,10-diaza-bicyclo[4.3.1]decane

There total 4 articles about 10-Benzyl-8-oxa-3,10-diaza-bicyclo[4.3.1]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decan-4-one (1085458-59-8) → 10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane (1085458-63-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

tert-butyl 10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane-3-carboxylate (1085458-61-2) → 10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane (1085458-63-4)

Guidance literature:

tert-butyl 10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane-3-carboxylate; With hydrogenchloride; In ethyl acetate; for 2h;

With sodium carbonate; In ethanol; chloroform;

Reference yield:

N-benzyl-7-oxa-9-azabicyclo<3.3.1>nonan-3-one (81514-40-1) → 10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane (1085458-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide; sulfuric acid / chloroform / 1 h / 5 - 50 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; sodium azide; sulfuric acid; In tetrahydrofuran; chloroform;

upstream raw materials:

N-benzyl-7-oxa-9-azabicyclo<3.3.1>nonan-3-one

10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decan-4-one

tert-butyl 10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane-3-carboxylate

Downstream raw materials:

tert-butyl 10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane-3-carboxylate

tert-butyl 10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane-3-carboxylate

3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

(1R,6S)-10-benzyl-8-oxa-3,10-diazabicyclo[4.3.1]decane