3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

Base Information

Chemical Name:3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane
CAS No.:1085458-32-7
Molecular Formula:C₂₄H₂₂FN₇O₂
Molecular Weight:459.483
Hs Code.:

Synonyms:3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

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Chemical Property of 3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

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Technology Process of 3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

There total 13 articles about 3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113082-27-2
2-chloro-6-fluoroquinazoline

: 1085458-70-3
C₁₆H₁₉N₅O₂

: 1085458-32-7
3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

Guidance literature:: 2-chloro-6-fluoroquinazoline; C₁₆H₁₉N₅O₂; With triethylamine; In N,N-dimethyl-formamide; at 50 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 81514-40-1
N-benzyl-7-oxa-9-azabicyclo<3.3.1>nonan-3-one

: 1085458-32-7
3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide; sulfuric acid / chloroform / 1 h / 5 - 50 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

3.1: triethylamine / dichloromethane / 48 h / 20 °C

4.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2 h

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 50 °C

6.1: trifluoroacetic acid / dichloromethane

7.1: triethylamine / N,N-dimethyl-formamide / 50 °C

With lithium aluminium tetrahydride; sodium azide; sulfuric acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 1085458-32-7
3-(6-fluoroquinazolin-2-yl)-10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 50 °C

3: trifluoroacetic acid / dichloromethane

4: triethylamine / N,N-dimethyl-formamide / 50 °C

With benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;