Fosravuconazole

Base Information

Chemical Name:Fosravuconazole
CAS No.:351227-64-0
Molecular Formula:C₂₃H₂₀F₂N₅O₅PS
Molecular Weight:547.479
Hs Code.:
UNII:L4Q6O5430L
DSSTox Substance ID:DTXSID70188627
Nikkaji Number:J2.037.512D
Wikipedia:Fosravuconazole
Wikidata:Q27116141
NCI Thesaurus Code:C175721
Metabolomics Workbench ID:155341
ChEMBL ID:CHEMBL333325
Mol file:351227-64-0.mol

Synonyms:BMS-379224

Suppliers and Price of Fosravuconazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of Fosravuconazole

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:547.08908325
Heavy Atom Count:37
Complexity:859

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)OCOP(=O)(O)O
Isomeric SMILES:C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)OCOP(=O)(O)O
Recent ClinicalTrials:Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan
Recent NIPH Clinical Trials:Usefulness of additional treatment after oral drug treatment for complete cure of Onychomycosis.

Technology Process of Fosravuconazole

There total 2 articles about Fosravuconazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

: 351227-63-9
di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

: 942415-34-1
C₂₇H₃₀F₂N₅O₆PS

: 351227-64-0
4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazol]benzonitrile

Guidance literature:: With hydrogenchloride; methanol; at 0 ℃; for 4h; Product distribution / selectivity;

Reference yield:

: 351227-63-9
di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

: 351227-64-0
4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazol]benzonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2003.08.029

Reference yield:

: 351227-64-0
4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazol]benzonitrile

: ((2R,3R)-3-(4-(4-cyanophenyl)-thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-yloxy)methyl dihydrogenphosphate mono-L-lysine salt ethanol solvate

Guidance literature:: 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazol]benzonitrile; With L-lysine; In methanol; at 60 ℃; for 4.5h; pH=4.2 - 5.5;

In methanol; ethanol; at 65 ℃;