di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

Base Information

Chemical Name:di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate
CAS No.:351227-63-9
Molecular Formula:C₃₁H₃₆F₂N₅O₅PS
Molecular Weight:659.694
Hs Code.:

Synonyms:di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

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Chemical Property of di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

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Technology Process of di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

There total 1 articles about di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182760-06-1
ravuconazole

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: 351227-63-9
di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

Guidance literature:: ravuconazole; With iodine; sodium hydride; In tetrahydrofuran;

di-tert-butyl chloromethyl phosphate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.08.029

Reference yield: 99.7%

: 351227-63-9
di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

: 942415-34-1
C₂₇H₃₀F₂N₅O₆PS

: 351227-64-0
4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazol]benzonitrile

Guidance literature:: With hydrogenchloride; methanol; at 0 ℃; for 4h; Product distribution / selectivity;

Reference yield: 67.0%

: 64-17-5
ethanol

: 56-87-1,3506-25-0
L-lysine

: 351227-63-9
di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate

: 914361-45-8
lysine [{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)-1-propyl}oxy]methyl dihydrogenphosphate ethanol (1/1/1)

Guidance literature:: di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate; With hydrogenchloride; water; In methanol; at -20 - 0 ℃; for 5.23h;

With potassium phosphate; dipotassium hydrogenphosphate; disodium hydrogenphosphate; In methanol; water; ethyl acetate;

ethanol; L-lysine; With hydrogenchloride; acetic acid; more than 3 stages; Product distribution / selectivity;