(2R,3S,5R)-5-(4-chloro-2-isobutyramido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

Base Information

Chemical Name:(2R,3S,5R)-5-(4-chloro-2-isobutyramido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate
CAS No.:1111663-99-0
Molecular Formula:C₃₁H₃₁ClN₄O₆
Molecular Weight:591.063
Hs Code.:
Mol file:1111663-99-0.mol

Synonyms:(2R,3S,5R)-5-(4-chloro-2-isobutyramido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

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Chemical Property of (2R,3S,5R)-5-(4-chloro-2-isobutyramido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

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Technology Process of (2R,3S,5R)-5-(4-chloro-2-isobutyramido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

There total 3 articles about (2R,3S,5R)-5-(4-chloro-2-isobutyramido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 104291-20-5
(2R,3S,5R)-5-(2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

: 79-30-1
isobutyryl chloride

: 1111663-99-0
6-chloro-7-deaza-N⁽²⁾-isobutyryl-3',5',-di-O-p-toluoyl-2'-deoxyguanosine

Guidance literature:: With pyridine; at 0 - 20 ℃;
DOI:10.1021/ol802719a

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1111663-99-0
6-chloro-7-deaza-N⁽²⁾-isobutyryl-3',5',-di-O-p-toluoyl-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / acetonitrile / 0.08 h / 20 °C

1.2: 0.33 h / 20 °C

2.1: pyridine / 20 °C

With pyridine; potassium hydroxide; In acetonitrile;
DOI:10.1016/j.tet.2013.11.048

Reference yield:

: 3056-12-0,3601-89-6,4330-21-6,52304-86-6,141846-57-3
2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride

: 1111663-99-0
6-chloro-7-deaza-N⁽²⁾-isobutyryl-3',5',-di-O-p-toluoyl-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / acetonitrile / 0.08 h / 20 °C

1.2: 0.33 h / 20 °C

2.1: pyridine / 20 °C

With pyridine; potassium hydroxide; In acetonitrile;
DOI:10.1016/j.tet.2013.11.048