7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
• CAS No.: 174462-91-0
• Molecular Formula: C₁₅H₁₉IN₄O₅
• Molecular Weight: 462.244
• Mol file: 174462-91-0.mol

Synonyms:7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Chemical Property of 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

There total 10 articles about 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-[2-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (1529801-45-3) → 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (174462-91-0)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.tet.2013.11.048

Reference yield: 89.0%

7-iodo-7-deaza-2'-deoxyguanosine (172163-62-1) → 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (174462-91-0)

Guidance literature:

With chloro-trimethyl-silane; ammonia; In pyridine; water;

Reference yield: 89.0%

2-Methylpropionic anhydride (97-72-3) + 7-iodo-7-deaza-2'-deoxyguanosine (172163-62-1) → 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (174462-91-0)

Guidance literature:

With chloro-trimethyl-silane; In pyridine; for 3h; Ambient temperature;

upstream raw materials:

2-Methylpropionic anhydride

7-iodo-7-deaza-2'-deoxyguanosine

isobutyryl chloride

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Downstream raw materials:

7-iodo-7-deaza-2'-deoxyguanosine

N-{7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-4-oxo-5-[5-(2,2,2-trifluoro-acetylamino)-pent-1-ynyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-isobutyramide

N-(7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-hex-1-ynyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-isobutyramide

N-{7-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-prop-1-ynyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-isobutyramide