Neurodazine

Base Information

• Chemical Name: Neurodazine
• CAS No.: 937807-66-4
• Molecular Formula: C₂₇H₂₁ClN₂O₃
• Molecular Weight: 456.928
• European Community (EC) Number: 633-610-6
• ChEMBL ID: CHEMBL4303639
• DSSTox Substance ID: DTXSID60583006
• Nikkaji Number: J2.503.839H
• Wikidata: Q27166384
• Mol file: 937807-66-4.mol

Synonyms:Neurodazine;937807-66-4;2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole;2-[5-(3-Chloro-phenyl)-furan-2-yl]-4,5-bis-(4-methoxy-phenyl)-1H-imidazole;2-[5-(3-Chlorophenyl)furan-2-yl]-4,5-bis(4-methoxyphenyl)-1H-imidazole;CHEMBL4303639;SCHEMBL12869707;CHEBI:94546;Neurodazine, >=98% (HPLC);DTXSID60583006;FEEOFPAEDSMOTO-UHFFFAOYSA-N;HMS3414E07;HMS3648I16;HMS3678E07;AKOS024457732;Neurodazine - CAS 937807-66-4;NCGC00344091-03;BN162802;MS-28339;HY-108439;CS-0028665;G13532;SR-01000946376;SR-01000946376-1;BRD-K22631935-001-01-9;Q27166384

Chemical Property of Neurodazine

Chemical Property:

• Boiling Point: 661.4±55.0 °C(Predicted)
• PKA: 12.84±0.10(Predicted)
• PSA: 56.37000
• Density: 1.252±0.06 g/cm3(Predicted)
• LogP: 7.00710
• Storage Temp.: Store at +4°C
• Solubility.: DMSO: >20mg/mL
• XLogP3: 6.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 456.1240702
• Heavy Atom Count: 33
• Complexity: 608

Purity/Quality:

97% ^*data from raw suppliers

Neurodazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=C(O3)C4=CC(=CC=C4)Cl)C5=CC=C(C=C5)OC
• Description: Neurodazine (937807-66-4) was able to induce neurogenesis of non-pluripotent myoblasts and cells derived from mature, human skeletal muscle (using 2 μM neurodazine). It was able to upregulate genes involved in neurogenesis (particularly B-cell translocation gene 2) without affecting those involved in myogenesis.
• Uses: Neurodazine induces neurogenesis in mature skeletal muscle cells, via non-pluripotent C2C12 myoblasts.

Technology Process of Neurodazine

There total 10 articles about Neurodazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-benzyl-2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole (1448032-73-2) → 2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole (937807-66-4)

Guidance literature:

With potassium tert-butylate; oxygen; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 0.166667h;

DOI:10.1021/jo501664p

Reference yield: 74.0%

2-[5-(3-chlorophenyl)furan-2-yl]-4,5-di(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole (1448032-74-3) → 2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole (937807-66-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 80 ℃; for 4h;

DOI:10.1055/s-0032-1316906

Reference yield:

5-(3-chlorophenyl)-2-furancarboxaldehyde (22078-59-7) + 1,2-bis(4-methoxyphenyl)-1,2-ethanedione (1226-42-2) → 2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole (937807-66-4)

Guidance literature:

With ammonium acetate; acetic acid; at 100 ℃; for 6h;

DOI:10.1021/ja072817z

upstream raw materials:

5-(3-chlorophenyl)-2-furancarboxaldehyde

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

1-benzyl-4,5-dibromo-2-(2-furyl)-1H-imidazole

4,5-dibromo-2-(2-furyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole