1448032-73-2

Basic information

• Product Name: 1-benzyl-2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole
• Synonyms: 1-benzyl-2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole
• CAS NO: 1448032-73-2
• Molecular Weight: 547.053
• Mol File: 1448032-73-2.mol

Chemical Properties

• CAS DataBase Reference: 1-benzyl-2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole(1448032-73-2)
• EPA Substance Registry System: 1-benzyl-2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole(1448032-73-2)

Safety Data

• Hazardous Substances Data: 1448032-73-2(Hazardous Substances Data)

Upstream product

• 1448032-43-6 1-benzyl-4,5-dibromo-2-(2-furyl)-1H-imidazole 
• 100-39-0 benzyl bromide 
• 1448032-60-7 1-benzyl-2-(furan-2-yl)-4,5-(4-methoxyphenyl)-1H-imidazole 
• 31250-80-3 1-benzyl-2,4,5-tribromo-1H-imidazole 
• 1448032-71-0 1-benzyl-2-(5-bromofuran-2-yl)-4,5-di(4-methoxyphenyl)-1H-imidazole 
• 63503-60-6 3-chlorophenylboronic acid 

Downstream Products

• 937807-66-4 2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole 

Relevant articles and documents

Triorganoindium reagents in selective palladium-catalyzed cross-coupling with iodoimidazoles: Synthesis of neurodazine

Triorganoindium reagents (R3In, R = aryl, heteroaryl, alkynyl) react selectively under palladium catalysis with N-benzyl-2,4,5-triiodoimidazole to afford the C-2 monocoupling products. The reaction proceeds efficiently for a variety of aryl- and heteroarylindium reagents with the transfer of all three organic groups attached to the metal. The coupling products can be used in a subsequent two-fold cross-coupling to give trisubstituted imidazoles in good yields. This approach was employed to synthesize neurodazine and analogues in good yields. (Chemical Equation Presented).

Selective sequential cross-coupling reactions on imidazole towards neurodazine and analogues

Polysubstituted imidazoles represent a common structural motif in bioactive molecules. A modular and flexible strategy towards 2,4,5-triarylated imidazoles is reported applying a Suzuki-Miyaura cross-coupling protocol. Employing 1-protected 2,4,5-tribromoimidazole as starting material, both stepwise and one-pot protocols towards the title compounds are disclosed. The utility of the approach was demonstrated by synthesizing neurodazine, a biologically active molecule affecting neuronal cell differentiation.