tert-Butyl 4-(2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl)piperazine-1-carboxyla

Base Information

• Chemical Name: tert-Butyl 4-(2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl)piperazine-1-carboxyla
• CAS No.: 1310404-00-2
• Molecular Formula: C₂₃H₃₇BN₂O₅
• Molecular Weight: 432.368
• Hs Code.: 2934999090
• Mol file: 1310404-00-2.mol

Synonyms:tert-Butyl 4-(2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl)piperazine-1-carboxyla;tert-Butyl 4-(2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)piperazine-1-carboxylate;tert-Butyl 4-{2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl}piperazine-1-carbo

Chemical Property of tert-Butyl 4-(2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl)piperazine-1-carboxyla

Chemical Property:

• PSA: 60.47000
• LogP: 2.79310
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

Tert-Butyl4-(2-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-Yl)Phenoxy]Ethyl)Piperazine-1-Carboxyla ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl)piperazine-1-carboxyla

There total 3 articles about tert-Butyl 4-(2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl)piperazine-1-carboxyla which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl 4-(2-(4-bromophenoxy)ethyl)piperazine-1-carboxylate + bis(pinacol)diborane (73183-34-3) → tert-butyl 4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)piperazine-1-carboxylate (1310404-00-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; water; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (77279-24-4) → tert-butyl 4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)piperazine-1-carboxylate (1310404-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 20 °C

1.2: 18 h / 100 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; methanesulfonyl chloride; triethylamine; In 1,4-dioxane; dichloromethane; water;

Reference yield:

4-bromo-phenol (106-41-2) → tert-butyl 4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)piperazine-1-carboxylate (1310404-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 20 °C

1.2: 18 h / 100 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; methanesulfonyl chloride; triethylamine; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate

4-bromo-phenol

bis(pinacol)diborane

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