2'-Amino-biphenyl-4-OL

Base Information

Chemical Name:2'-Amino-biphenyl-4-OL
CAS No.:65975-66-8
Molecular Formula:C₁₂H₁₁NO
Molecular Weight:185.225
Hs Code.:
ChEMBL ID:CHEMBL3813748
DSSTox Substance ID:DTXSID301309012

Synonyms:2'-AMINO-BIPHENYL-4-OL;65975-66-8;SCHEMBL3405995;CHEMBL3813748;DTXSID301309012;2'-Amino[1,1'-biphenyl]-4-ol;AKOS006294911

Suppliers and Price of 2'-Amino-biphenyl-4-OL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2'-Amino-biphenyl-4-OL

Chemical Property:

PSA：46.25000
LogP:3.22260
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:185.084063974
Heavy Atom Count:14
Complexity:175

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=CC=C(C=C2)O)N

Technology Process of 2'-Amino-biphenyl-4-OL

There total 5 articles about 2'-Amino-biphenyl-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855254-26-1
2'-amino-biphenyl-4-sulfonic acid

: 65975-66-8
2'-amino-1,1'-biphenyl-4-ol

Guidance literature:: With sodium hydroxide; water; at 295 - 310 ℃;

Reference yield:

: 577-19-5
2-nitrophenyl bromide

: 65975-66-8
2'-amino-1,1'-biphenyl-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 0.17 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: ammonium chloride; iron / water; isopropyl alcohol / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; In water; isopropyl alcohol; toluene; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.5b00659