2-cyclopropylpropan-2-aMine

Base Information

• Chemical Name: 2-cyclopropylpropan-2-aMine
• CAS No.: 172947-13-6
• Molecular Formula: C6H13N
• Molecular Weight: 99.17412
• Mol file: 172947-13-6.mol

Synonyms:2-cyclopropylpropan-2-aMine;(1-cyclopropyl-1-methylethyl)amine hydrochloride;MFCD23144031;a,a-Dimethyl Cyclopropanemethanamine;1-Cyclopropyl-1-methyl-ethylamine;2-cyclopropylpropan-2-aminehydrochloride

Chemical Property of 2-cyclopropylpropan-2-aMine

Chemical Property:

• PSA: 26.02000
• LogP: 1.83400

Purity/Quality:

97% ^*data from raw suppliers

2-Cyclopropylpropan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Cyclopropylpropan-2-amine was a useful reagent in sysntehsis of 8-Aminomethyltetracycline deriatives as novel antibacterial agents.

Technology Process of 2-cyclopropylpropan-2-aMine

There total 3 articles about 2-cyclopropylpropan-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-azidopropan-2-yl)cyclopropane → 2-cyclopropylpropan-2-amine (172947-13-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Reflux;

Reference yield:

2-cyclopropyl-2-propanol (930-39-2) → 2-cyclopropylpropan-2-amine (172947-13-6)

Guidance literature:

Multistep reaction; (i) BrCN, NaH, THF, (ii) aq. HCl;

DOI:10.1021/jo01275a012

Reference yield:

Cyclopropyl methyl ketone (765-43-5) → 2-cyclopropylpropan-2-amine (172947-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 20 °C / Reflux

2: sodium azide; trichloroacetic acid / chloroform / 2 h / 20 °C

3: lithium aluminium tetrahydride / diethyl ether / 2 h / Reflux

With lithium aluminium tetrahydride; sodium azide; trichloroacetic acid; In diethyl ether; chloroform;

upstream raw materials:

2-cyclopropyl-2-propanol

Cyclopropyl methyl ketone