tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate

Base Information

• Chemical Name: tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate
• CAS No.: 1298101-47-9
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Mol file: 1298101-47-9.mol

Synonyms:tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate;(1s,3r)-3-amino-1-(boc-amino)cyclohexane;tert-butyl N-[(1S,3R)-3-aminocyclohexyl]carbamate

Chemical Property of tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate

Chemical Property:

• PSA: 64.35000
• LogP: 2.87220
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.0% ^*data from raw suppliers

tert-butylN-[(1S,3R)-3-aminocyclohexyl]carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate

There total 11 articles about tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[3-(1S,3R)-benzyloxycarbonylaminocyclohexyl]-1-carbamic acid tertbutyl ester (1261225-48-2) → ((1S,3R)-3-aminocyclohexyl)carbamic acid tert-butyl ester (1298101-47-9,1788036-28-1,609788-04-7,849616-22-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 5h; under 760.051 Torr;

Reference yield:

[3-(1R,3S)-benzyloxycarbonylaminocyclohexyl]-1-carbamic acid tertbutyl ester (1261225-49-3) → ((1S,3R)-3-aminocyclohexyl)carbamic acid tert-butyl ester (1298101-47-9,1788036-28-1,609788-04-7,849616-22-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; under 750.075 Torr; Inert atmosphere;

Reference yield:

(1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid (227783-08-6) → ((1S,3R)-3-aminocyclohexyl)carbamic acid tert-butyl ester (1298101-47-9,1788036-28-1,609788-04-7,849616-22-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 110 °C

1.2: 70 - 85 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C

3.1: ammonium bicarbonate / pyridine / 1,4-dioxane / 3 h

3.2: 1 h

4.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile; water / 20 °C

5.1: potassium carbonate / tetrahydrofuran / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 750.08 Torr / Inert atmosphere

With diphenyl phosphoryl azide; hydrogen; ammonium bicarbonate; potassium carbonate; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; pyridine; palladium 10% on activated carbon; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; toluene; acetonitrile;

upstream raw materials:

ethyl (1R,3S)-3-aminocyclohexanecarboxylate

(1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid

[3-(1R,3S)-benzyloxycarbonylaminocyclohexyl]-1-carbamic acid tertbutyl ester

ethyl (1R,3S)-3-benzyloxycarbonylaminocyclohexane-1-carboxylate

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