methyl 3-amino-2-bromo-5-fluorobenzoate

Base Information

• Chemical Name: methyl 3-amino-2-bromo-5-fluorobenzoate
• CAS No.: 1342063-52-8
• Molecular Formula: C8H7BrFNO2
• Molecular Weight: 248.051
• Hs Code.: 2916399090
• Mol file: 1342063-52-8.mol

Synonyms:methyl 3-amino-2-bromo-5-fluorobenzoate;methyl 2-bromo-5-fluoro-3-aminobenzoate

Chemical Property of methyl 3-amino-2-bromo-5-fluorobenzoate

Chemical Property:

• Boiling Point: 322.8±42.0 °C(Predicted)
• PKA: 0.38±0.10(Predicted)
• PSA: 52.32000
• Density: 1.653±0.06 g/cm3(Predicted)
• LogP: 2.53820
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

≥99.0% ^*data from raw suppliers

Methyl 3-amino-2-bromo-5-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-amino-2-bromo-5-fluorobenzoate

There total 3 articles about methyl 3-amino-2-bromo-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 2-bromo-5-fluoro-3-nitrobenzoate (328547-12-2) → methyl 3-amino-2-bromo-5-fluorobenzoate (1342063-52-8)

Guidance literature:

With iron; acetic acid; In ethanol; at 85 ℃; for 1h; Inert atmosphere;

Reference yield:

2-Bromo-5-fluorobenzoic acid (394-28-5) → methyl 3-amino-2-bromo-5-fluorobenzoate (1342063-52-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 2.5 h / 5 - 10 °C / Inert atmosphere

2: thionyl chloride / 1 h / 10 - 65 °C / Inert atmosphere

3: acetic acid; iron / ethanol / 1 h / 85 °C / Inert atmosphere

With thionyl chloride; sulfuric acid; nitric acid; iron; acetic acid; In ethanol;

Reference yield:

2-bromo-5-fluoro-3-nitrobenzoic acid (1055331-73-1) → methyl 3-amino-2-bromo-5-fluorobenzoate (1342063-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / 10 - 65 °C / Inert atmosphere

2: acetic acid; iron / ethanol / 1 h / 85 °C / Inert atmosphere

With thionyl chloride; iron; acetic acid; In ethanol;

upstream raw materials:

2-Bromo-5-fluorobenzoic acid

2-bromo-5-fluoro-3-nitrobenzoic acid

methyl 2-bromo-5-fluoro-3-nitrobenzoate

Downstream raw materials:

(R)-benzyl 2-((4-fluoro-2-(methoxycarbonyl)-6-(2,2,2-trifluoroacetamido)phenyl)ethynyl)-2-methylpyrrolidine-1-carboxylate

(R)-methyl 9-fluoro-11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate

(10aR)-2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one

methyl 3-amino-5-fluorobenzoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1342063-52-8 methyl 3-amino-2-bromo-5-fluorobenzoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send