p-Propylsulfonylacetanilide

Base Information

• Chemical Name: p-Propylsulfonylacetanilide
• CAS No.: 86810-69-7
• Molecular Formula: C11H15NO3S
• Molecular Weight: 0
• Mol file: 86810-69-7.mol

Synonyms:p-Propylsulfonylacetanilide

Chemical Property of p-Propylsulfonylacetanilide

Chemical Property:

• PSA: 71.62000
• LogP: 2.98250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-Propylsulfonylacetanilide

There total 4 articles about p-Propylsulfonylacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4-acetylaminophenyl)boronic acid (101251-09-6) + propyl bromide (106-94-5) → N-[4-(propylsulfonyl)phenyl]acetamide (86810-69-7)

Guidance literature:

(4-acetylaminophenyl)boronic acid; With dichloro bis(acetonitrile) palladium(II); potassium pyrosulfite; tetrabutylammomium bromide; tert-butyl XPhos; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

propyl bromide; In N,N-dimethyl-formamide; at 85 ℃; for 22h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201505918

Reference yield:

sodium 4-acetamidobenzenesulfinate (15898-43-8) + 1-iodo-propane (107-08-4) → N-[4-(propylsulfonyl)phenyl]acetamide (86810-69-7)

Guidance literature:

With ethanol;

DOI:10.1021/jo01148a029

Reference yield:

p-acetylaminobenzenesulfonyl chloride (121-60-8) → N-[4-(propylsulfonyl)phenyl]acetamide (86810-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂SO₃, 30percent NaOH / H₂O / 2 h / 50 °C

2: 164.3 g / ethanol; H₂O / 24 h / Heating

With sodium hydroxide; sodium sulfite; In ethanol; water;

DOI:10.1002/hlca.19830660407

upstream raw materials:

sodium 4-acetamidobenzenesulfinate

1-iodo-propane

4-acetamidobenzenesulfinic acid

propyl bromide

Downstream raw materials:

(4-Aminophenyl)-propyl-sulfon

Refernces

• 1、 Courtin, Alfred. "Syntheses of Some Alkyl-, Cycloalkyl-, and Aryl-(4-aminophenyl)-sulfones". . p. 1046 - 1052. Retrieved 2007/10/02.