tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1430563-87-3
Molecular Formula:C₂₇H₂₈N₄O₅
Molecular Weight:0
Hs Code.:
Mol file:1430563-87-3.mol

Synonyms:tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

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Technology Process of tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 9 articles about tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2835-68-9
4-aminobenzamide

: C₂₀H₂₂N₂O₅

: 1430563-87-3
tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 1430563-86-2
2-tert-butyl 1-methyl 5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

: 1430563-87-3
tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran / 3 h

2: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1430563-92-0
5-bromo-2-(tert-butoxycarbonyl)-3,4-dihydroisoquinoline-1-carboxylic acid methyl ester

: 1430563-87-3
tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide; 1,10-Phenanthroline / dimethyl sulfoxide / 130 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 3 h

3: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h

With copper(l) iodide; 1,10-Phenanthroline; water; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;