(E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

Base Information

Chemical Name:(E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide
CAS No.:1430562-69-8
Molecular Formula:C₃₂H₂₄ClFN₈O₄
Molecular Weight:639.045
Hs Code.:

(E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

Synonyms:(E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

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Chemical Property of (E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

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Technology Process of (E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

There total 12 articles about (E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094107-98-8
(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

: C₂₂H₂₀N₄O₃

: 1430562-69-8
(E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 142-08-5
2-hydroxypyridin

: 1430562-69-8
(E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; copper(l) iodide; 1,10-Phenanthroline / dimethyl sulfoxide / 130 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 3 h

3: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h

4: trifluoroacetic acid / dichloromethane / 24 h

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With copper(l) iodide; 1,10-Phenanthroline; water; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1430563-86-2
2-tert-butyl 1-methyl 5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

: 1430562-69-8
(E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide; water / tetrahydrofuran / 3 h

2: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h

3: trifluoroacetic acid / dichloromethane / 24 h

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;