endo-9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane

Base Information

• Chemical Name: endo-9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane
• CAS No.: 1148006-31-8
• Molecular Formula: C12H21NO4
• Molecular Weight: 243.303
• Mol file: 1148006-31-8.mol

Synonyms:endo-9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane;endo-tert-Butyl 7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate;(Meso-1R,5S,7S)-Tert-Butyl 7-Hydroxy-3-Oxa-9-Azabicyclo[3.3.1]Nonane-9-Carboxylate

Chemical Property of endo-9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane

Chemical Property:

• Boiling Point: 357.8±42.0 °C(Predicted)
• PKA: 14.60±0.20(Predicted)
• PSA: 59.00000
• Density: 1.175±0.06 g/cm3(Predicted)
• LogP: 1.08350

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl(1S,5S)-7-Hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of endo-9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane

There total 6 articles about endo-9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-oxo-3-oxa-9-aza-bicyclo[3.3.1]nonane-9-carboxylic acid tert-butyl ester → (1R,5S,7S)-tert-butyl 7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate (1148006-31-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 2h;

Reference yield:

tert-butyl 7-oxo-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate (280761-97-9) → (1R,5S,7S)-tert-butyl 7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate (1148006-31-8)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 1h;

Reference yield:

(1R,5S)-9-benzyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-one → (1R,5S,7S)-tert-butyl 7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate (1148006-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; palladium on activated charcoal; hydrogen / water; ethanol / 18 h / 25 °C

2: triethylamine / ethanol / 6 h / 25 °C

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 25 °C / Cooling with ice

With hydrogenchloride; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; water;

upstream raw materials:

N-benzyl-7-oxa-9-azabicyclo<3.3.1>nonan-3-one

3-oxa-9-azabicyclo[3.3.1]nonan-7-one

tert-butyl 7-oxo-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate

Downstream raw materials:

tert-butyl (1R,5S,7r)-7-((4-nitrobenzoyl)oxy)-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate

C₂₄H₂₈ClN₅O₄

C₂₄H₃₁ClN₄O₆S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1148006-31-8 endo-9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane

Send

Send

Metric Ton KG G Pound L ML

Send

Send