tert-butyl4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate
CAS No.:1196531-33-5
Molecular Formula:C₁₈H₂₄N₂O₄
Molecular Weight:332.4
Hs Code.:
Mol file:1196531-33-5.mol

Synonyms:tert-butyl4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate

Suppliers and Price of tert-butyl4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of tert-butyl4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

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Technology Process of tert-butyl4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate

There total 1 articles about tert-butyl4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 52805-46-6
2-methoxy-5-cyanophenol

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1196531-33-5
tert-butyl 4-(5-cyano-2-methoxy-phenoxy)piperidine-1-carboxylate

Guidance literature:: With potassium carbonate; In isopropyl alcohol; Reflux;

Reference yield: 94.0%

: 1196531-33-5
tert-butyl 4-(5-cyano-2-methoxy-phenoxy)piperidine-1-carboxylate

: 1196531-36-8
4-methoxy-3-(4-piperidyloxy)benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; water; In ethanol; at 40 - 60 ℃; for 3h;

Reference yield:

: 1196531-33-5
tert-butyl 4-(5-cyano-2-methoxy-phenoxy)piperidine-1-carboxylate

: 848942-61-0
Sapitinib

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / isopropyl alcohol / 75 - 85 °C / Inert atmosphere; Industrial scale

2.1: triethanolamine / ethanol / 12 h / 80 - 81 °C / Inert atmosphere; Industrial scale

3.1: acetic acid; sulfuric acid; nitric acid / 42 - 48 °C / Inert atmosphere; Industrial scale

4.1: 1 % platinum and 2% vanadium on carbon / acetonitrile / 40 °C / Inert atmosphere; Industrial scale

4.2: 6 h / 40 °C / 2250.23 Torr / Industrial scale

5.1: 2-methyltetrahydrofuran; acetic acid / 8 h / 79 - 90 °C / Inert atmosphere; Industrial scale

With hydrogenchloride; triethanolamine; sulfuric acid; 1 % platinum and 2% vanadium on carbon; nitric acid; acetic acid; In 2-methyltetrahydrofuran; ethanol; acetic acid; isopropyl alcohol; acetonitrile; 5.1: |Dimroth Rearrangement;
DOI:10.1021/acs.oprd.6b00412