2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate
• CAS No.: 623144-25-2
• Molecular Formula: C₁₆H₈Cl₂F₃NO₃S
• Molecular Weight: 422.212
• Mol file: 623144-25-2.mol

Synonyms:2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate

Chemical Property of 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate

There total 5 articles about 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2,6-dichlorophenyl)-6-quinolinol (623144-24-1) + trifluoromethylsulfonic anhydride (358-23-6) → 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate (623144-25-2)

Guidance literature:

In dichloromethane;

DOI:10.1016/j.bmcl.2006.09.069

Reference yield:

6-(benzyloxy)-2-chloroquinoline (623144-17-2) → 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate (623144-25-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / Pd(PPh₃)4; NaHCO₃ / toluene; ethanol

2: 100 percent / BBr₃ / CH₂Cl₂

3: 100 percent / CH₂Cl₂

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium hydrogencarbonate; In ethanol; dichloromethane; toluene;

DOI:10.1016/j.bmcl.2006.09.069

Reference yield:

6-(benzyloxy)-2-(2,6-dichlorophenyl)quinoline (623144-23-0) → 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate (623144-25-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / BBr₃ / CH₂Cl₂

2: 100 percent / CH₂Cl₂

With boron tribromide; In dichloromethane;

DOI:10.1016/j.bmcl.2006.09.069

upstream raw materials:

2-(2,6-dichlorophenyl)-6-quinolinol

trifluoromethylsulfonic anhydride

6-(benzyloxy)-2-chloroquinoline

6-(benzyloxy)-2-(2,6-dichlorophenyl)quinoline