623144-17-2

Upstream product

• 19315-93-6 quinoline-2,6-diol 
• 577967-89-6 6-hydroxy-2-chloroquinoline 
• 100-39-0 benzyl bromide 

Downstream Products

• 1541189-33-6 C₂₂H₂₃N₃O₂ 
• 1202682-42-5 6-benzyloxy-2-(2,2,6,6-tetramethyl-piperidin-4-yloxy)-quinoline 
• 623144-18-3 6-(benzyloxy)-2-phenoxyquinoline 
• 623144-25-2 2-(2,6-dichlorophenyl)-6-quinolinyl trifluoromethanesulfonate 
• 623144-24-1 2-(2,6-dichlorophenyl)-6-quinolinol 
• 623144-23-0 6-(benzyloxy)-2-(2,6-dichlorophenyl)quinoline 

Relevant academic research and scientific papers

INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these com-pounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

NOVEL TETRAMETHYL SUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

This invention relates to novel tetramethyl substituted pipehdine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

2,6-Quinolinyl derivatives as potent VLA-4 antagonists

A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.

2,6-QUINOLINYL AND 2,6-NAPHTHYL DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS VLA-4 INHIBITORS

The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.