(1R,6alpha)-1alpha-Methyl-2beta,4alpha-bis(tert-butyldimethylsiloxy)-7-oxabicyclo[4.1.0]heptane

Base Information

Chemical Name:(1R,6alpha)-1alpha-Methyl-2beta,4alpha-bis(tert-butyldimethylsiloxy)-7-oxabicyclo[4.1.0]heptane
CAS No.:121289-20-1
Molecular Formula:C19H40O3Si2
Molecular Weight:372.696
Hs Code.:
Nikkaji Number:J861.143B
Mol file:121289-20-1.mol

Synonyms:(1R,6alpha)-1alpha-Methyl-2beta,4alpha-bis(tert-butyldimethylsiloxy)-7-oxabicyclo[4.1.0]heptane

Suppliers and Price of (1R,6alpha)-1alpha-Methyl-2beta,4alpha-bis(tert-butyldimethylsiloxy)-7-oxabicyclo[4.1.0]heptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane1,2-Epoxide
50mg
$ 580.00

TRC
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane1,2-Epoxide
100mg
$ 1055.00

TRC
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane1,2-Epoxide
5mg
$ 70.00

Biosynth Carbosynth
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane 1,2-epoxide
100 mg
$ 1311.00

Biosynth Carbosynth
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane 1,2-epoxide
50 mg
$ 721.00

Biosynth Carbosynth
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane 1,2-epoxide
10 mg
$ 218.00

Biosynth Carbosynth
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane 1,2-epoxide
5 mg
$ 120.00

Biosynth Carbosynth
(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane 1,2-epoxide
25 mg
$ 396.50

AK Scientific
Tert-butyl-[[(1R,2R,4R,6R)-4-[tert-butyl(dimethyl)silyl]oxy-1-methyl-7-oxabicyclo[4.1.0]heptan-2-yl]oxy]-dimethylsilane
10mg
$ 344.00

Total 2 raw suppliers

Chemical Property of (1R,6alpha)-1alpha-Methyl-2beta,4alpha-bis(tert-butyldimethylsiloxy)-7-oxabicyclo[4.1.0]heptane

Chemical Property:

PSA：30.99000
LogP:5.71850
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:372.25159820
Heavy Atom Count:24
Complexity:476

Purity/Quality:

97% ^*data from raw suppliers

(1R,2S,4R,6R)-2,4-Bis(tert-butyldimethylsilyloxy)-1-methyl-cyclohexane1,2-Epoxide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12C(O1)CC(CC2O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
Isomeric SMILES:C[C@]12[C@H](O1)C[C@H](C[C@@H]2O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
Uses Intermediate in the preparation of Dihydroxyvitamin D3 and associated metabolites.

Technology Process of (1R,6alpha)-1alpha-Methyl-2beta,4alpha-bis(tert-butyldimethylsiloxy)-7-oxabicyclo[4.1.0]heptane

There total 12 articles about (1R,6alpha)-1alpha-Methyl-2beta,4alpha-bis(tert-butyldimethylsiloxy)-7-oxabicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 191849-78-2
(1S,2S,4S,6R)-1-Methyl-7-oxa-bicyclo[4.1.0]heptane-2,4-diol

: 121289-20-1
(1S,2S,4R,6R)-2,4-bis(tert-butyldimethylsilyloxy)-1-methyl-7-oxabicyclo[4.1.0]heptane

Guidance literature:: With 1H-imidazole;
DOI:10.1016/S0040-4039(97)01005-8

Reference yield: 80.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 132870-51-0
(1R,3R,5S,6S)-5-(tert-butyldimethylsilyloxy)-6-methyl-7-oxabicyclo[4.1.0]heptan-3-ol

: 121289-20-1
(1S,2S,4R,6R)-2,4-bis(tert-butyldimethylsilyloxy)-1-methyl-7-oxabicyclo[4.1.0]heptane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jo972285c

Reference yield:

: 35692-59-2
(1S,2S,4S,6R)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-2-ol

: 121289-20-1
(1S,2S,4R,6R)-2,4-bis(tert-butyldimethylsilyloxy)-1-methyl-7-oxabicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 4 steps

1.1: imidazole

2.1: OsO₄, KIO₄

2.2: MCPBA

3.1: K₂CO₃ / methanol

4.1: imidazole

With 1H-imidazole; osmium(VIII) oxide; potassium metaperiodate; potassium carbonate; In methanol; 1.1: Substitution / 2.1: Oxidation / 2.2: Oxidation / 3.1: Hydrolysis / 4.1: Substitution;
DOI:10.1080/15257779908041504