4(3H)-Quinazolinone, 7-[2-(4-Methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-

Base Information

Chemical Name:4(3H)-Quinazolinone, 7-[2-(4-Methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-
CAS No.:893428-67-6
Molecular Formula:C₂₀H₂₈N₄O₄
Molecular Weight:388.467
Hs Code.:2934999090
Mol file:893428-67-6.mol

Synonyms:4(3H)-Quinazolinone, 7-[2-(4-Methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-;7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4(3H)-one

Suppliers and Price of 4(3H)-Quinazolinone, 7-[2-(4-Methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
7-(2-(4-Methylpiperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one 95+%
1g
$ 772.00

Chemenu
7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one 95%
1g
$ 729.00

American Custom Chemicals Corporation
7-(2-(4-METHYLPIPERAZIN-1-YL)ETHOXY)-5-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)QUINAZOLIN-4(3H)-ONE 95.00%
5MG
$ 504.44

Alichem
7-(2-(4-Methylpiperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one
1g
$ 615.44

Total 6 raw suppliers

Chemical Property of 4(3H)-Quinazolinone, 7-[2-(4-Methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-

Chemical Property:

PSA：80.18000
LogP:1.39520
Storage Temp.:2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

7-(2-(4-Methylpiperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4(3H)-Quinazolinone, 7-[2-(4-Methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-

There total 5 articles about 4(3H)-Quinazolinone, 7-[2-(4-Methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

: 5464-12-0
2-(4-methylpiperazinyl)ethanol

: 379230-38-3
7-fluoro-N-(5-chloro-1,3-benzodioxol-4-yl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

: saracatinib

: 893428-67-6
C₂₀H₂₈N₄O₄

Guidance literature:: With sodium hydroxide; In toluene; at 104 - 106 ℃; for 9h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op200079g

Reference yield: 55.0%

: 893428-67-6
7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 379228-59-8
7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazoline-4(3H)-one

: 893428-67-6
7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one

Guidance literature:: 2-(4-methylpiperazinyl)ethanol; With potassium tert-butylate; In tetrahydrofuran; for 0.166667h;

7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazoline-4(3H)-one; In tetrahydrofuran; for 19h; Heating / reflux;