N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine

Base Information

Chemical Name:N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine
CAS No.:379230-38-3
Molecular Formula:C20H17ClFN3O4
Molecular Weight:417.81800
Hs Code.:2934999090
DSSTox Substance ID:DTXSID00470108
Wikidata:Q72453946
Mol file:379230-38-3.mol

Synonyms:379230-38-3;N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine;N-(5-chloro-1,3-benzodioxol-4-yl)-7-fluoro-5-(oxan-4-yloxy)quinazolin-4-amine;N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine;7-fluoro-N-(5-chloro-1,3-benzodioxol-4-yl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine;SCHEMBL3276447;DTXSID00470108;PVOAJSAAENFMPF-UHFFFAOYSA-N;BCP07608;4-(6-chloro-2,3-methylenedioxyanilino)-7-fluoro-5-tetrahydropyran-4-yloxyquinazoline;N-(5-Chloro-2H-1,3-benzodioxol-4-yl)-7-fluoro-5-[(oxan-4-yl)oxy]quinazolin-4-amine

Suppliers and Price of N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine 95+%
1g
$ 1647.00

Matrix Scientific
N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine 95+%
250mg
$ 742.00

Crysdot
N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine 95+%
1g
$ 772.00

Chemenu
N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine 95%
1g
$ 729.00

American Custom Chemicals Corporation
N-(5-CHLOROBENZO[D]-[1,3]-DIOXOL-4-YL)-7-FLUORO-5-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)QUINAZOLIN-4-AMINE 95.00%
5MG
$ 497.29

Alichem
N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine
1g
$ 646.84

AK Scientific
N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine
250mg
$ 1051.00

Total 10 raw suppliers

Chemical Property of N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine

Chemical Property:

PSA：74.73000
Density:1.487
LogP:4.52540
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:417.0891619
Heavy Atom Count:29
Complexity:558

Purity/Quality:

98%+ ^*data from raw suppliers

N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCC1OC2=CC(=CC3=C2C(=NC=N3)NC4=C(C=CC5=C4OCO5)Cl)F

Technology Process of N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine

There total 7 articles about N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2081-44-9
Tetrahydro-pyran-4-ol

: 893428-69-8
4-(6-chloro-2,3-methylenedioxyanilino)-5,7-difluoroquinazoline

: 379230-38-3
7-fluoro-N-(5-chloro-1,3-benzodioxol-4-yl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

Guidance literature:: With sodium tert-pentoxide; In 1-methyl-pyrrolidin-2-one; at 55 ℃; for 5h; Large scale reaction;
DOI:10.1021/op200079g

Reference yield: 80.0%

: 2081-44-9
Tetrahydro-pyran-4-ol

: 893428-68-7
5,7-difluoro-N-(5-chloro-1,3-benzodioxol-4-yl)quinazolin-4-amine hydrochloride

: 379230-38-3
7-fluoro-N-(5-chloro-1,3-benzodioxol-4-yl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

Guidance literature:: 5,7-difluoro-N-(5-chloro-1,3-benzodioxol-4-yl)quinazolin-4-amine hydrochloride; With sodium tert-pentoxide; In 1-methyl-pyrrolidin-2-one;

Tetrahydro-pyran-4-ol; With sodium tert-pentoxide; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 2.5h;
DOI:10.1021/op100163m

Reference yield:

: 893428-68-7
5,7-difluoro-N-(5-chloro-1,3-benzodioxol-4-yl)quinazolin-4-amine hydrochloride

: 379230-38-3
7-fluoro-N-(5-chloro-1,3-benzodioxol-4-yl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

Guidance literature:: Tetrahydro-pyran-4-ol; With potassium tert-butylate; In tetrahydrofuran; for 0.333333h;

5,7-difluoro-N-(5-chloro-1,3-benzodioxol-4-yl)quinazolin-4-amine hydrochloride; In tetrahydrofuran; at 50 ℃; for 4.58333h; Product distribution / selectivity; Heating / reflux;