Technology Process of 4-Bromo-2-phenoxybenzonitrile
There total 3 articles about 4-Bromo-2-phenoxybenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenol;
With
potassium carbonate;
In
N,N-dimethyl-formamide; toluene;
for 4h;
Dean-Stark;
Inert atmosphere;
Reflux;
4-bromo-6-fluorobenzonitrile;
In
N,N-dimethyl-formamide; toluene;
for 4h;
Reflux;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 8 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
With
potassium carbonate; sodium hydroxide;
In
water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201706597
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Lumogen F Orange 240; dipotassium hydrogenphosphate / acetonitrile / 26 h / 40 °C / Irradiation; Inert atmosphere
2: sodium hydroxide / water / 8 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
With
dipotassium hydrogenphosphate; potassium carbonate; Lumogen F Orange 240; sodium hydroxide;
In
water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201706597
