Cyclopenta[b]pyrrole-2-carboxylic acid, octahydro-, (2R,3aR,6aR)- (9CI)

Base Information

• Chemical Name: Cyclopenta[b]pyrrole-2-carboxylic acid, octahydro-, (2R,3aR,6aR)- (9CI)
• CAS No.: 128900-19-6
• Molecular Formula: C8H13NO2
• Molecular Weight: 155.197
• Mol file: 128900-19-6.mol

Synonyms:Cyclopenta[b]pyrrole-2-carboxylic acid, octahydro-, (2R,3aR,6aR)- (9CI)

Chemical Property of Cyclopenta[b]pyrrole-2-carboxylic acid, octahydro-, (2R,3aR,6aR)- (9CI)

Chemical Property:

• Boiling Point: 304.3±25.0 °C(Predicted)
• PKA: 2.47±0.20(Predicted)
• PSA: 49.33000
• Density: 1.182±0.06 g/cm3(Predicted)
• LogP: 0.93040

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Cyclopenta[b]pyrrole-2-carboxylic acid, octahydro-, (2R,3aR,6aR)- (9CI)

There total 8 articles about Cyclopenta[b]pyrrole-2-carboxylic acid, octahydro-, (2R,3aR,6aR)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(all-R)-2-Azabicyclo[3.3.0]octan-3-oic acid benzyl ester p-toluenesulfonate (129101-19-5) → (1R,3R,5R)-2-azabicyclo<3.3.0>octane-3-carboxylic acid (128900-19-6,411232-21-8,726691-28-7)

Guidance literature:

palladium on activated charcoal; In cyclohexene; for 4h; Heating;

Reference yield: 74.0%

(2R,3aS,6aR)-1-Acetyl-octahydro-cyclopenta[b]pyrrole-2-carbonitrile (87623-98-1,88585-95-9,89299-92-3,89299-93-4,110549-38-7,110549-39-8) → (2S,3aR,6aS)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid (87679-21-8,87679-60-5,88547-76-6,88547-86-8,93381-12-5,96844-79-0,105307-53-7,109428-53-7,118353-96-1,121154-36-7,128900-19-6,411232-21-8,726691-28-7)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1016/S0040-4039(00)87864-8

Reference yield: 33.0%

(4R,5aR,8aR,9aR)-4-Phenyl-octahydro-cyclopenta[4,5]pyrrolo[2,1-c][1,4]oxazin-1-one (147406-85-7) → (1R,3R,5R)-2-azabicyclo<3.3.0>octane-3-carboxylic acid (128900-19-6,411232-21-8,726691-28-7)

Guidance literature:

With hydrogen; trifluoroacetic acid; palladium hydroxide - carbon; In methanol;

DOI:10.1016/0040-4039(93)88116-Z

upstream raw materials:

(all-R)-2-Azabicyclo[3.3.0]octan-3-oic acid benzyl ester p-toluenesulfonate

(4R,5aR,8aR,9aR)-4-Phenyl-octahydro-cyclopenta[4,5]pyrrolo[2,1-c][1,4]oxazin-1-one

(2R,8R,12S)-12-phenyl-1-aza-10-oxatricyclo<6.4.0.0^2,6>dodec-6-en-9-one

(2R,3aS,6aR)-1-Acetyl-octahydro-cyclopenta[b]pyrrole-2-carbonitrile

Downstream raw materials:

(1R,3R,5R)-2-(benzyloxycarbonyl)-2-azabicyclo<3.3.0>octane-3-carboxylic acid

(2R,3aR,6aR)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

(2R,3aR,6aR)-1-Benzyl-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

(2R,3aR,6aR)-1-(4-Vinyl-benzyl)-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

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