6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine

Base Information

• Chemical Name: 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine
• CAS No.: 943006-45-9
• Molecular Formula: C5H5ClFN3
• Molecular Weight: 161.566
• Hs Code.: 2933599590
• Mol file: 943006-45-9.mol

Synonyms:6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine;6-chloro-5-fluoro-2-methyl-4-Pyrimidinamine

Chemical Property of 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine

Chemical Property:

• PSA: 52.53000
• LogP: 1.08980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

6-Chloro-5-fluoro-2-methylpyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine

There total 1 articles about 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4,6-dichloro-5-fluoro-2-methylpyrimidine (105806-13-1) → 6-chloro-5-fluoro-2-methylpyrimidin-4-amine (943006-45-9)

Guidance literature:

With ammonia; In 1,4-dioxane; water; at 70 ℃; for 2h; sealed tube; Inert atmosphere;

DOI:10.1021/jm300184s

Reference yield: 57.0%

6-chloro-5-fluoro-2-methylpyrimidin-4-amine (943006-45-9) + 2-bromo-5-(3-ethoxy-benzenesulfonyl)-thiazole (943006-34-6) → (6-chloro-5-fluoro-2-methyl-pyrimidin-4-yl)-[5-(3-ethoxy-benzenesulfonyl)-thiazol-2-yl]-amine (943006-40-4)

Guidance literature:

6-chloro-5-fluoro-2-methylpyrimidin-4-amine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

2-bromo-5-(3-ethoxy-benzenesulfonyl)-thiazole; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 1.75h;

upstream raw materials:

4,6-dichloro-5-fluoro-2-methylpyrimidine

Downstream raw materials:

(6-chloro-5-fluoro-2-methyl-pyrimidin-4-yl)-[5-(3-ethoxy-benzenesulfonyl)-thiazol-2-yl]-amine

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