105806-13-1

Basic information

• Product Name: 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE
• Synonyms: 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE;2-Methyl-4,6-dichloro-5-fluoropyrimidine;PyriMidine, 4,6-dichloro-5-fluoro-2-Methyl-
• CAS NO: 105806-13-1
• Molecular Formula: C₅H₃Cl₂FN₂
• Molecular Weight: 181
• Product Categories: Fluorine series
• Mol File: 105806-13-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 221℃
• Flash Point: 87℃
• Appearance: Yellow power
• Density: 1.504
• Vapor Pressure: 0.167mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.96±0.39(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE(105806-13-1)
• EPA Substance Registry System: 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE(105806-13-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 105806-13-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H3Cl2FN2/c1-2-9-4(6)3(8)5(7)10-2/h1H3

Upstream product

• 1598-63-6 5-fluoro-4,6-dihydroxy-2-methylpyrimidine 

Downstream Products

• 1152107-25-9 GSK1322322 
• 1152110-20-7 [(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-4-pyrimidinyl}hydrazino)-3-oxopropyl][(phenylmethyl)oxy]formamide 
• 943006-45-9 6-chloro-5-fluoro-2-methylpyrimidin-4-amine 
• 1383976-40-6 4-chloro-5-fluoro-6-methoxy-2-methylpyrimidine 

Relevant articles and documents

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3- oxopropyl}hydroxyformamide compounds of Formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity and in treatment methods for bacterial infections

CALCIUM CHANNEL ANTAGONISTS

The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists.

PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF

The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson’s disease, epilepsy, and addiction.