5-Phenyl-1,3-thiazole-2-carbaldehyde

Base Information

• Chemical Name: 5-Phenyl-1,3-thiazole-2-carbaldehyde
• CAS No.: 862494-59-5
• Molecular Formula: C10H7NOS
• Molecular Weight: 189.238
• European Community (EC) Number: 826-419-6
• Mol file: 862494-59-5.mol

Synonyms:5-phenyl-1,3-thiazole-2-carbaldehyde;862494-59-5;5-PHENYLTHIAZOLE-2-CARBALDEHYDE;SCHEMBL3505055;5-phenyl-thiazole-2-carbaldehyde;KOEXIFWBDMYROV-UHFFFAOYSA-N;2-Thiazolecarboxaldehyde, 5-phenyl-;MFCD11846732;AKOS005211595;SB21804;AS-34850;CS-0050410;EN300-124972;Z1037606604

Chemical Property of 5-Phenyl-1,3-thiazole-2-carbaldehyde

Chemical Property:

• PSA: 58.20000
• LogP: 2.62260
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 189.02483502
• Heavy Atom Count: 13
• Complexity: 180

Purity/Quality:

97% ^*data from raw suppliers

5-Phenyl-1,3-thiazole-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(S2)C=O

Technology Process of 5-Phenyl-1,3-thiazole-2-carbaldehyde

There total 1 articles about 5-Phenyl-1,3-thiazole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.1%

5-bromothiazole-2-carbaldehyde (933752-44-4) + phenylboronic acid (98-80-6) → 5-phenylthiazole-2-carbaldehyde (862494-59-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 12h; Inert atmosphere;

Reference yield: 62.0%

5-phenylthiazole-2-carbaldehyde (862494-59-5) + oseltamivir phosphate (204255-11-8) → ethyl (3R,4R,5S)-4-acetamido-3-(pentan-3-yloxy)-5-(((5-phenylthiazol-2-yl)methyl)amino)cyclohex-1-ene-1-carboxylate

Guidance literature:

With sodium cyanoborohydride; In methanol; ethanol; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2020.112147

Reference yield:

3-(2-Methyl-piperidino)-propylamin (25560-00-3) + 5-phenylthiazole-2-carbaldehyde (862494-59-5) → [3-(2-methyl-piperidin-1-yl)-propyl]-(5-phenyl-thiazol-2ylmethyl)-amine (862494-56-2)

Guidance literature:

In dichloromethane; at 20 ℃;

upstream raw materials:

5-bromothiazole-2-carbaldehyde

phenylboronic acid

Downstream raw materials:

[3-(2-methyl-piperidin-1-yl)-propyl]-(5-phenyl-thiazol-2ylmethyl)-amine

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