N-(5-broMo-2-Methoxypyridin-3-yl)cyclopropanesulfonaMide

Base Information

• Chemical Name: N-(5-broMo-2-Methoxypyridin-3-yl)cyclopropanesulfonaMide
• CAS No.: 1083326-05-9
• Molecular Formula: C9H11BrN2O3S
• Molecular Weight: 307.168
• Hs Code.: 2935009090
• Mol file: 1083326-05-9.mol

Synonyms:N-(5-broMo-2-Methoxypyridin-3-yl)cyclopropanesulfonaMide;N-(5-bromo-2-methoxy-3-pyridinyl)cyclopropanesulfonamide

Chemical Property of N-(5-broMo-2-Methoxypyridin-3-yl)cyclopropanesulfonaMide

Chemical Property:

• PSA: 76.67000
• LogP: 2.91060
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

N-(5-Bromo-2-methoxypyridin-3-yl)cyclopropanesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-broMo-2-Methoxypyridin-3-yl)cyclopropanesulfonaMide

There total 8 articles about N-(5-broMo-2-Methoxypyridin-3-yl)cyclopropanesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-2-(methyloxy)-3-pyridinamine (884495-39-0) + cyclopropanesulfonyl chloride (139631-62-2) → N-(5-bromo-2-methoxy-pyridine-3-yl)cyclopropyl-sulfonamide (1083326-05-9)

Guidance literature:

With dmap; In pyridine; at 20 ℃; for 72h;

Reference yield: 89.9%

→ N-(5-bromo-2-methoxy-pyridine-3-yl)cyclopropyl-sulfonamide (1083326-05-9)

Guidance literature:

With pyridine; at 20 ℃; for 22h;

With sodium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield:

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → N-(5-bromo-2-methoxy-pyridine-3-yl)cyclopropyl-sulfonamide (1083326-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium / 20 °C / Cooling

1.2: 17 h / 0 - 20 °C

2.1: iron; ammonium chloride / ethanol; water / 15 h / Reflux

3.1: pyridine / 23 h / 20 - 60 °C

With pyridine; sodium; iron; ammonium chloride; In ethanol; water;

upstream raw materials:

5-bromo-2-(methyloxy)-3-pyridinamine

cyclopropanesulfonyl chloride

5-bromo-2-methoxy-3-nitropyridine

5-bromo-2-chloro-3-nitropyridine

Downstream raw materials:

N-{2-(methyloxy)-5-[3-(4-{[2-(methyloxy)phenyl]sulfonyl}-1-piperazinyl)-6-quinoxalinyl]-3-pyridinyl}cyclopropanesulfonamide

N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridin-3-yl)cyclopropanesulfonamide

N-[5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide