PeMetrexed EP IMpurity A

Base Information

Chemical Name:PeMetrexed EP IMpurity A
CAS No.:869791-42-4
Molecular Formula:C₂₁H₂₃N₅O₆
Molecular Weight:441.444
Hs Code.:
Mol file:869791-42-4.mol

Synonyms:PeMetrexed EP IMpurity A;N-Methyl Pemetrexed;PeMetrexed IMpurity

Suppliers and Price of PeMetrexed EP IMpurity A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-MethylPemetrexed
2.5mg
$ 185.00

Medical Isotopes, Inc.
N-MethylPemetrexed
2.5 mg
$ 650.00

Total 11 raw suppliers

Chemical Property of PeMetrexed EP IMpurity A

Chemical Property:

PKA:3.58±0.10(Predicted)
Density:1.52±0.1 g/cm3(Predicted)
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:Basic Alcohol (Slightly), DMSO (Slightly), Water (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

N-MethylPemetrexed ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-Methyl Pemetrexed is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.

Technology Process of PeMetrexed EP IMpurity A

There total 5 articles about PeMetrexed EP IMpurity A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid diethyl ester

: 869791-42-4
(2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

Guidance literature:: With sodium hydroxide; In water; at 20 ℃; for 2h;
DOI:10.3390/molecules200610004

Reference yield: 5.0%

: N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt

: 74-88-4
methyl iodide

: 869791-42-4
(2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

Guidance literature:: With triethylamine;
DOI:10.3390/molecules200610004

Reference yield:

: 165049-28-5
N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 4-methylbenzenesulfonic acid salt

: 869791-42-4
(2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

2: sodium hydroxide / water / 2 h / 20 °C

With triethylamine; sodium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.3390/molecules200610004