4-AMino-3-Methanesulfonylbenzoic acid

Base Information

• Chemical Name: 4-AMino-3-Methanesulfonylbenzoic acid
• CAS No.: 34263-58-6
• Molecular Formula: C8H9NO4S
• Molecular Weight: 215.22636
• Hs Code.: 2922499990
• Mol file: 34263-58-6.mol

Synonyms:4-AMino-3-Methanesulfonylbenzoic acid;4-amino-3-(methylsulfonyl)benzoic acid

Chemical Property of 4-AMino-3-Methanesulfonylbenzoic acid

Chemical Property:

• PSA: 105.84000
• LogP: 2.03250

Purity/Quality:

95+% ^*data from raw suppliers

4-Amino-3-methanesulfonylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMino-3-Methanesulfonylbenzoic acid

There total 6 articles about 4-AMino-3-Methanesulfonylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzylamino-3-methylsulfonylbenzoic acid → 4-Amino-3-methylsulfonylbenzoesaeure (34263-58-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol;

DOI:10.1016/j.bmcl.2003.08.040

Reference yield:

4-chloro-3-(chlorosulfonyl)benzoic acid (2494-79-3) → 4-Amino-3-methylsulfonylbenzoesaeure (34263-58-6)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH; Na₂SO₃

2: aq. NaOH / methanol

3: 55 percent / 140 °C

4: 100 percent / H₂ / Pd/C / dioxane; methanol

With sodium hydroxide; hydrogen; sodium sulfite; palladium on activated charcoal; In 1,4-dioxane; methanol;

DOI:10.1016/j.bmcl.2003.08.040

Reference yield:

3-methylsulphonyl-4-chlorobenzoic acid (51522-07-7) → 4-Amino-3-methylsulfonylbenzoesaeure (34263-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / 140 °C

2: 100 percent / H₂ / Pd/C / dioxane; methanol

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol;

DOI:10.1016/j.bmcl.2003.08.040

upstream raw materials:

4-chloro-3-(chlorosulfonyl)benzoic acid

3-methylsulphonyl-4-chlorobenzoic acid

4-Chloro-3-hydroxysulfinylbenzoic acid

para-chlorobenzoic acid

Downstream raw materials:

methyl 4-amino-3-methanesulfonylbenzoate

methyl 4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-3-methanesulfonylbenzoate

TY-51076

Refernces