(4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:(4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane
CAS No.:1228077-93-7
Molecular Formula:C14H19N3O3
Molecular Weight:277.32
Hs Code.:2932999099
European Community (EC) Number:693-347-8
DSSTox Substance ID:DTXSID80584313
Mol file:1228077-93-7.mol

Synonyms:1228077-93-7;(4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane;(4S)-4-[(1R)-2-azido-1-phenylmethoxyethyl]-2,2-dimethyl-1,3-dioxolane;1,3-Dioxolane, 4-[(1R)-2-azido-1-(phenylmethoxy)ethyl]-2,2-dimethyl-, (4S)-;SCHEMBL23162022;DTXSID80584313;AKOS025294202;J-004859

Suppliers and Price of (4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
(4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane
1g
$ 363.00

American Custom Chemicals Corporation
(4S)-4-[(1R)-2-AZIDO-1-(BENZYLOXY)ETHYL]-2,2-DIMETHYL-1,3-DIOXOLANE 95.00%
1G
$ 1047.82

Total 1 raw suppliers

Chemical Property of (4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane

Chemical Property:

Refractive Index:n20/D 1.5090(lit.)
Flash Point:218 °F
PSA：77.44000
Density:1.116 g/mL at 25 °C(lit.)
LogP:2.48636
Storage Temp.:2-8°C
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:277.14264148
Heavy Atom Count:20
Complexity:350

Purity/Quality:: (4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22
Safety Statements: 36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(OCC(O1)C(CN=[N+]=[N-])OCC2=CC=CC=C2)C
Isomeric SMILES:CC1(OC[C@H](O1)[C@@H](CN=[N+]=[N-])OCC2=CC=CC=C2)C

Technology Process of (4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane

There total 5 articles about (4S)-4-[(1R)-2-Azido-1-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 115689-99-1
Methanesulfonic acid (S)-2-benzyloxy-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester

: 143365-04-2,1228077-93-7
(2S,3S)-4-azido-3-benzyloxy-1,2-O-isopropylidene-1,2-butanediol

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 48h;
DOI:10.1016/S0957-4166(02)00223-9

Reference yield:

: 100-39-0
benzyl bromide

: 143365-04-2,1228077-93-7
(2S,3S)-4-azido-3-benzyloxy-1,2-O-isopropylidene-1,2-butanediol

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / Ag₂O; molecular sieves / 4 h / 20 °C

2: 90 percent / LiCl; NaBH₄ / tetrahydrofuran; ethanol / 20 h / 0 - 20 °C

3: 99 percent / pyridine / CH₂Cl₂ / 20 h / 20 °C

4: 81 percent / NaN₃ / dimethylformamide / 48 h / 60 °C

With pyridine; sodium tetrahydroborate; sodium azide; molecular sieve; lithium chloride; silver(l) oxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(02)00223-9

Reference yield:

: 84379-53-3
2-O-benzyl-3,4-O-isopropylidene-L-threitol

: 143365-04-2,1228077-93-7
(2S,3S)-4-azido-3-benzyloxy-1,2-O-isopropylidene-1,2-butanediol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / pyridine / CH₂Cl₂ / 20 h / 20 °C

2: 81 percent / NaN₃ / dimethylformamide / 48 h / 60 °C

With pyridine; sodium azide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(02)00223-9