5-(M-tolyl)pentanoic acid

Base Information

• Chemical Name: 5-(M-tolyl)pentanoic acid
• CAS No.: 105401-68-1
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol file: 105401-68-1.mol

Synonyms:5-(M-tolyl)pentanoic acid;3-methylbenzenepentanoic acid

Chemical Property of 5-(M-tolyl)pentanoic acid

Chemical Property:

• Boiling Point: 83 - 84 °C (27 mmHg)
• PSA: 37.30000
• LogP: 2.79240

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(M-tolyl)pentanoic acid

There total 5 articles about 5-(M-tolyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-m-tolyl-pent-4-enoic acid (870679-58-6) → 5-(m-tolyl)pentanoic acid (105401-68-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃; for 2h;

DOI:10.1021/jm050317f

Reference yield:

(3-carboxypropyl)(triphenyl)phosphonium bromide (17857-14-6) → 5-(m-tolyl)pentanoic acid (105401-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuOK / dimethylsulfoxide / 0.33 h / 20 °C

1.2: 69 percent / dimethylsulfoxide / 4 h / 20 °C

2.1: 96 percent / H₂ / PtO₂ / ethanol / 2 h / 20 °C

With potassium tert-butylate; hydrogen; platinum(IV) oxide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm050317f

Reference yield:

(2E,4E)-5-m-Tolyl-penta-2,4-dienoic acid (226719-38-6) → 5-(m-tolyl)pentanoic acid (105401-68-1)

Guidance literature:

With hydrogen;

DOI:10.1021/jm00367a005

upstream raw materials:

(2E,4E)-5-m-Tolyl-penta-2,4-dienoic acid

5-m-tolyl-pent-4-enoic acid

(3-carboxypropyl)(triphenyl)phosphonium bromide

m-tolyl aldehyde

Downstream raw materials:

ethyl 8-methyl-1-(2',4'-dichlorophenyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxylate

8-methyl-1-(2',4'-dichlorophenyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxylic acid

Refernces

• 1、 Murineddu, Gabriele,Ruiu, Stefania,Loriga, Giovanni,Manca, Ilaria,Lazzari, Paolo,Reali, Roberta,Pani, Luca,Toma, Lucio,Pinna, Gérard A.. "Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2′, 4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7] cyclohepta[1,2-c]pyrazole-3-carboxamide". . p. 7351 - 7362. Retrieved 2007/10/03.
• 2、 Wong,Sasso,Jones,Kaminski. "Stereochemical considerations and the antiinflammatory activity of 6-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols and related derivatives". . p. 20 - 27. Retrieved 2007/10/02.