4-PyriMidinecarboxylic acid, 6-chloro-2-Methyl-, ethyl ester

Base Information

• Chemical Name: 4-PyriMidinecarboxylic acid, 6-chloro-2-Methyl-, ethyl ester
• CAS No.: 744253-37-0
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.625
• Hs Code.: 2933599090
• Mol file: 744253-37-0.mol

Synonyms:4-PyriMidinecarboxylic acid, 6-chloro-2-Methyl-, ethyl ester;Ethyl 6-chloro-2-MethylpyriMidine-4-carboxylate

Chemical Property of 4-PyriMidinecarboxylic acid, 6-chloro-2-Methyl-, ethyl ester

Chemical Property:

• PSA: 52.08000
• LogP: 1.61510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-chloro-2-methylpyrimidine-4-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PyriMidinecarboxylic acid, 6-chloro-2-Methyl-, ethyl ester

There total 3 articles about 4-PyriMidinecarboxylic acid, 6-chloro-2-Methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-hydroxy-2-methyl-pyrimidine-4-carboxylic acid ethyl ester (159326-53-1) → 6-chloro-2-methylpyrimidine-4-carboxylic acid ethyl ester (744253-37-0)

Guidance literature:

With trichlorophosphate; Heating;

DOI:10.1016/j.bmcl.2004.05.072

Reference yield:

(Z)-2-chloro-2-butenedioic acid, diethyl ester (10302-94-0) → 6-chloro-2-methylpyrimidine-4-carboxylic acid ethyl ester (744253-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / ethanol

2: 100 percent / POCl₃ / Heating

With sodium ethanolate; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2004.05.072

Reference yield:

diethyl Fumarate (623-91-6) → 6-chloro-2-methylpyrimidine-4-carboxylic acid ethyl ester (744253-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Cl₂ / CH₂Cl₂

1.2: NaOEt / ethanol

2.1: NaOEt / ethanol

3.1: 100 percent / POCl₃ / Heating

With sodium ethanolate; chlorine; trichlorophosphate; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2004.05.072

upstream raw materials:

6-hydroxy-2-methyl-pyrimidine-4-carboxylic acid ethyl ester

(Z)-2-chloro-2-butenedioic acid, diethyl ester

diethyl Fumarate