2-pyridone-5-boronic ester

Base Information

• Chemical Name: 2-pyridone-5-boronic ester
• CAS No.: 1219130-53-6
• Molecular Formula: C₁₅H₁₈BNO₃
• Molecular Weight: 271.124
• Mol file: 1219130-53-6.mol

Synonyms:2-pyridone-5-boronic ester;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-2(1H)-one

Chemical Property of 2-pyridone-5-boronic ester

Chemical Property:

• PSA: 51.32000
• LogP: 1.82730
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-pyridone-5-boronic ester

There total 3 articles about 2-pyridone-5-boronic ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromoquinolin-2(1H)-one (99465-09-5) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolone (1219130-53-6)

Guidance literature:

With C₅₄H₄₄NO₂PPdS; potassium acetate; In 2-methyltetrahydrofuran; at 90 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02414

Reference yield:

N-(3-bromophenyl)cinnamamide (349426-35-3) + bis(pinacol)diborane (73183-34-3) → 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-quinolin-2-one (1219130-54-7) + 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolone (1219130-53-6)

Guidance literature:

N-(3-bromophenyl)cinnamamide; With aluminum (III) chloride; chlorobenzene; at 0 - 12 ℃;

bis(pinacol)diborane; With potassium 2-ethylhexanoate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 80 ℃; for 1.5h; Inert atmosphere;

Reference yield:

→ 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolone (1219130-53-6)

Guidance literature:

upstream raw materials:

N-(3-bromophenyl)cinnamamide

bis(pinacol)diborane

5-bromoquinolin-2(1H)-one

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