2,2-Dimethylpropane-1-sulfonamide

Base Information

• Chemical Name: 2,2-Dimethylpropane-1-sulfonamide
• CAS No.: 206066-14-0
• Molecular Formula: C5H13NO2S
• Molecular Weight: 151.22722
• European Community (EC) Number: 841-529-4
• Mol file: 206066-14-0.mol

Synonyms:2,2-DIMETHYLPROPANE-1-SULFONAMIDE;206066-14-0;neopentanesulfonamide;Neopentylsulfonamide;Neopentyl Sulfonamide;SCHEMBL223990;2,2-dimethylpropanesulfonamide;VQXWDAAONGOPPT-UHFFFAOYSA-N;AKOS011362781;DB-255695;EN300-75955;G57723;Z954606228

Chemical Property of 2,2-Dimethylpropane-1-sulfonamide

Chemical Property:

• PSA: 68.54000
• LogP: 2.10210
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.06669983
• Heavy Atom Count: 9
• Complexity: 170

Purity/Quality:

99% ^*data from raw suppliers

Neopentanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)CS(=O)(=O)N
• Uses: Neopentanesulfonamide is used in the preparation of macrocyclic peptides as hepatitis C virus inhibitors.

Technology Process of 2,2-Dimethylpropane-1-sulfonamide

There total 5 articles about 2,2-Dimethylpropane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

→ 2,2-dimethylpropane-1-sulfonamide (206066-14-0)

Guidance literature:

Reference yield:

2,2-dimethylpropylmagnesium chloride (13132-23-5) → 2,2-dimethylpropane-1-sulfonamide (206066-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; sulfuryl chloride

2: diethyl ether; ammonia

With sulfuryl dichloride; diethyl ether; ammonia;

DOI:10.1021/jo01110a002

Reference yield:

2,2-dimethylpropane (463-82-1) → 2,2-dimethylpropane-1-sulfonamide (206066-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrachloromethane; sulfur dioxide; chlorine / unter Belichtung

2: diethyl ether; ammonia

With tetrachloromethane; diethyl ether; sulfur dioxide; ammonia; chlorine;

DOI:10.1021/jo01110a002

upstream raw materials:

2,2-dimethyl-propane-1-sulfonyl chloride

2,2-dimethylpropane

2,2-dimethylpropylmagnesium chloride