5-(4-chlorokphenyl)pentanoic acid

Base Information

• Chemical Name: 5-(4-chlorokphenyl)pentanoic acid
• CAS No.: 161725-12-8
• Molecular Formula: C11H13ClO2
• Molecular Weight: 212.676
• Mol file: 161725-12-8.mol

Synonyms:5-(4-chlorokphenyl)pentanoic acid

Chemical Property of 5-(4-chlorokphenyl)pentanoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 3.13740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

5-(4-chlorophenyl)pentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-chlorokphenyl)pentanoic acid

There total 13 articles about 5-(4-chlorokphenyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-(4-chloro-phenyl)-pentanoic acid ethyl ester (371111-51-2) → 5-(4-chlorophenyl)pentanoic acid (161725-12-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 5h;

DOI:10.1016/S0040-4020(02)00511-2

Reference yield: 75.0%

carbon dioxide (124-38-9,18923-20-1) + 4-(p-chlorophenyl)-1-butene (3047-24-3) → 5-(4-chlorophenyl)pentanoic acid (161725-12-8)

Guidance literature:

4-(p-chlorophenyl)-1-butene; With iron(III) chloride; tributylphosphine; copper(I) bromide; In diethyl ether; at -20 ℃; for 0.0833333h; Inert atmosphere;

With cyclopentylmagnesium bromide; In diethyl ether; at -20 ℃; for 1h; Inert atmosphere;

carbon dioxide; Further stages;

DOI:10.1021/ja206745w

Reference yield: 73.0%

methyl 5-(4-chlorophenyl)-5-oxopentanoate (71354-29-5) → 5-(4-chlorophenyl)pentanoic acid (161725-12-8)

Guidance literature:

With hydrazine hydrate; calcium chloride; potassium hydroxide; In diethylene glycol; at 150 - 170 ℃; for 4h;

DOI:10.1021/jm4010434

upstream raw materials:

5-(4-chloro-phenyl)-pentanoic acid ethyl ester

ethyl-5-(4-chlorophenyl)pent-2-enoate

3-(p-chlorophenyl)propanol

3-(4-chlorophenyl)propionaldehyde

Downstream raw materials:

δ-(p-chlorophenyl)-δ-valerolactone

1-Hydroxy-5-<4-chlor-phenyl>-pentan

(S)-(2-{3-[((9S,12S)-12-Cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[17.2.2.1^3,7]tetracosa-1⁽²²⁾,3,5,7⁽²⁴⁾,19⁽²³⁾,20-hexaene-9-carbonyl)-amino]-2-oxo-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

[12S,9S]-(2-{3-[(12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diazatricyclo[17.2.2.1^3,7]tetracosa-1⁽²²⁾,3⁽²⁴⁾,4,6,19⁽²³⁾,20-hexaene-9-carbonyl)amino]-2-hydroxyhexanoylamino}acetylamino)-[S]-phenylacetic acid tert-butyl ester

Refernces

• 1、 Duhamel, Thomas,Mu?iz, Kilian. "Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids". . p. 933 - 936. Retrieved 2019/01/23.
• 2、 Louvel, Julien,Carvalho, Jo?o F.S.,Yu, Zhiyi,Soethoudt, Marjolein,Lenselink, Eelke B.,Klaasse, Elisabeth,Brussee, Johannes,Ijzerman, Adriaan P.. "Removal of human ether-à-go-go related gene (hERG) K+ channel affinity through rigidity: A case of clofilium analogues". . p. 9427 - 9440. Retrieved 2014/01/06.