371111-51-2Relevant academic research and scientific papers
Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design
Venkatraman, Srikanth,Njoroge, F. George,Girijavallabhan, Viyyoor M.,Madison, Vincent S.,Yao, Nanua H.,Prongay, Andrew J.,Butkiewicz, Nancy,Pichardo, John
, p. 5088 - 5091 (2007/10/03)
Hepatitus C virus (HCV) NS3, when bound to NS4A cofactor, facilitates development of mature virons by catalyzing cleavage of a polyprotein to form functional and structural proteins of HCV. The enzyme has a shallow binding pocket at the catalytic site, ma
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides
Marson, Charles M.,Serradji, Nawal,Rioja, Alphonso S.,Gastaud, Sebastien P.,Alao, John P.,Coombes, R. Charles,Vigushin, David M.
, p. 2477 - 2481 (2007/10/03)
Syntheses of (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides are described, some of which are potent inhibitors of histone deacetylase, a double bond conferring more than a 10-fold increase in potency compared with the triple bond analogue oxamflatin.
Application of ruthenium induced cyclization for construction of strained biaryl ether macrocyclic compounds
Venkatraman, Srikanth,George Njoroge,Girijavallabhan, Viyyoor
, p. 5453 - 5458 (2007/10/03)
Synthesis of strained macrocyclic biaryl ethers of type 1 and 2 were accomplished using η6-ruthenium-induced macroetherification. This novel application demonstrates the versatility of this method in construction of constrained macrocyclic biar
