2-Naphthalenecarboxylic acid, 7-(phenylMethoxy)-4-[[(trifluoroMethyl)sulfonyl]oxy]-, ethyl ester

Base Information

• Chemical Name: 2-Naphthalenecarboxylic acid, 7-(phenylMethoxy)-4-[[(trifluoroMethyl)sulfonyl]oxy]-, ethyl ester
• CAS No.: 1160271-23-7
• Molecular Formula: C21H17F3O6S
• Molecular Weight: 454.424
• Mol file: 1160271-23-7.mol

Synonyms:2-Naphthalenecarboxylic acid, 7-(phenylMethoxy)-4-[[(trifluoroMethyl)sulfonyl]oxy]-, ethyl ester

Chemical Property of 2-Naphthalenecarboxylic acid, 7-(phenylMethoxy)-4-[[(trifluoroMethyl)sulfonyl]oxy]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Naphthalenecarboxylic acid, 7-(phenylMethoxy)-4-[[(trifluoroMethyl)sulfonyl]oxy]-, ethyl ester

There total 1 articles about 2-Naphthalenecarboxylic acid, 7-(phenylMethoxy)-4-[[(trifluoroMethyl)sulfonyl]oxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate (1160270-73-4) → ethyl 7-(benzyloxy)-4-{[(trifluoromethyl)sulfonyl]oxy}-2-naphthoate (1160271-23-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

Thien-3-ylboronic acid (6165-69-1) + ethyl 7-(benzyloxy)-4-{[(trifluoromethyl)sulfonyl]oxy}-2-naphthoate (1160271-23-7) → ethyl 7-(benzyloxy)-4-(3-thienyl)-2-naphthoate (1160271-24-8)

Guidance literature:

With potassium phosphate; CyJohnPhos; palladium diacetate; In 1,4-dioxane; water; at 80 ℃; for 1h;

Reference yield:

ethyl 7-(benzyloxy)-4-{[(trifluoromethyl)sulfonyl]oxy}-2-naphthoate (1160271-23-7) + phenylboronic acid (98-80-6) → C26H22O3

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In N,N-dimethyl-formamide; at 85 ℃;

DOI:10.1016/j.bmcl.2011.03.081

upstream raw materials:

trifluoromethylsulfonic anhydride

ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

Downstream raw materials:

ethyl 7-(benzyloxy)-4-(3-thienyl)-2-naphthoate

7-[(2,6-dimethylbenzyl)oxy]-4-(3-thienyl)-2-naphthoic acid

7-[(4-fluoro-2,6-dimethylbenzyl)oxy]-4-(3-thienyl)-2-naphthoic acid

C₁₉H₁₆O₃