ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

Base Information

Chemical Name:ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate
CAS No.:1160270-73-4
Molecular Formula:C₂₀H₁₈O₄
Molecular Weight:322.361
Hs Code.:

Synonyms:ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

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Chemical Property of ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

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Technology Process of ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

There total 1 articles about ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1160271-22-6
(3E)-4-[3-(benzyloxy)phenyl]-3-(ethoxycarbonyl)but-3-enoic acid

: 1160270-73-4
ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

Guidance literature:: (3E)-4-[3-(benzyloxy)phenyl]-3-(ethoxycarbonyl)but-3-enoic acid; With sodium acetate; In acetic anhydride; at 70 ℃; for 0.5h;

With potassium carbonate; In ethanol; acetic anhydride; at 70 - 80 ℃; for 7h;

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1160270-73-4
ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

: 1160271-23-7
ethyl 7-(benzyloxy)-4-{[(trifluoromethyl)sulfonyl]oxy}-2-naphthoate

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 1160270-73-4
ethyl 7-(benzyloxy)-4-hydroxy-2-naphthoate

: 1160271-20-4
7-[(4-fluoro-2,6-dimethylbenzyl)oxy]-4-(3-thienyl)-2-naphthoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide / 85 °C

3: palladium on carbon; hydrogen / ethyl acetate

4: potassium carbonate / N,N-dimethyl-formamide

5: sodium hydroxide / tetrahydrofuran; ethanol

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on carbon; hydrogen; sodium carbonate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.081