1-isobutyl-7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Base Information

• Chemical Name: 1-isobutyl-7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS No.: 175975-76-5
• Molecular Formula: C16H22N2O
• Molecular Weight: 258.363
• Mol file: 175975-76-5.mol

Synonyms:1-isobutyl-7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Chemical Property of 1-isobutyl-7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Chemical Property:

• PSA: 37.05000
• LogP: 3.73820

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Isobutyl-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-isobutyl-7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

There total 1 articles about 1-isobutyl-7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

diethyl 2-((2S,2'S,3R)-1-(tert-butoxycarbonyl)-2'-isobutyl-6-methoxyspiro[indoline-3,3'-pyrrolidine]-2-yl)malonate → 1-isobutyl-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (175975-76-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 24h;

DOI:10.1021/jo1002714

Reference yield: 69.4%

trans-4-((tert-butoxycarbonyl(methyl)amino)methyl)cyclohexanecarboxylic acid (165947-29-5) + 1-isobutyl-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (175975-76-5) → C30H45N3O4

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 17h;