N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]-Urea

Base Information

Chemical Name:N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]-Urea
CAS No.:1326239-56-8
Molecular Formula:C29H28F6N4O2
Molecular Weight:578.557
Hs Code.:
Mol file:1326239-56-8.mol

Synonyms:N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]-Urea

Suppliers and Price of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]-Urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Strem Chemicals
N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(9R)-6'-methoxycinchonan-9-yl]urea, 95%, (99% ee)
50mg
$ 109.00

Total 20 raw suppliers

Chemical Property of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]-Urea

Chemical Property:

Boiling Point:589.6±50.0 °C(Predicted)
PKA:11.85±0.46(Predicted)
Density:1.38±0.1 g/cm3(Predicted)

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(9R)-6'-methoxycinchonan-9-yl]urea, 95%, (99% ee) ^*data from reagent suppliers

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Technology Process of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]-Urea

There total 6 articles about N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]-Urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 287979-82-2
(R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanamine

: 16588-74-2
3,5-ditrifluoromethylisocyanate

: 1326239-56-8
C₂₉H₂₈F₆N₄O₂

Guidance literature:: (R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanamine; With diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 50 ℃; for 34h;

With triphenylphosphine; In tetrahydrofuran; at 50 ℃; for 15h;

3,5-ditrifluoromethylisocyanate; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/c3ob41938j

Reference yield:

: 56-54-2
quinidine

: 1326239-56-8
C₂₉H₂₈F₆N₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate; diphenyl phosphoryl azide / tetrahydrofuran / 49 h / 0 - 50 °C

2: tetrahydrofuran / 20 °C

With diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1002/chem.201701707